Detailed information NTG1154372

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: AD178_RS11060
• Genome accession: NZ_OX244288
• Coordinates: 2143974..2144099 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain PT8105 isolate 2RLC4
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2138974..2149099

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AD178_RS11030	-	2139313..2140987 (-)	1675	Protein_2144	YhgE/Pip domain-containing protein	-
AD178_RS11035 (SAMEA1463109_02228)	-	2141094..2141636 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AD178_RS11050 (SAMEA1463109_02231)	comE	2141879..2142631 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AD178_RS11055 (SAMEA1463109_02232)	comD/comD2	2142628..2143953 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
AD178_RS11060 (SAMEA1463109_02233)	comC/comC2	2143974..2144099 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
AD178_RS11070 (SAMEA1463109_02235)	rlmH	2144381..2144860 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AD178_RS11075 (SAMEA1463109_02236)	htrA	2145043..2146224 (+)	1182	WP_000681590.1	trypsin-like peptidase domain-containing protein	Regulator
AD178_RS11080 (SAMEA1463109_02237)	spo0J	2146282..2147040 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=1154372 AD178_RS11060 WP_000799686.1 2143974..2144099(-) (comC/comC2) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=1154372 AD178_RS11060 WP_000799686.1 2143974..2144099(-) (comC/comC2) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561