Detailed information NTG1152074

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: MMH06_RS02740
• Genome accession: NZ_OV904788
• Coordinates: 519521..520273 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain RMV7 isolate RMV7domi
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 514521..525273

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MMH06_RS02710 (IONPJBJN_00530)	spo0J	515112..515870 (-)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator
MMH06_RS02715 (IONPJBJN_00531)	htrA	515928..517109 (-)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
MMH06_RS02720 (IONPJBJN_00532)	rlmH	517292..517771 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
MMH06_RS02730 (IONPJBJN_00534)	comC/comC1	518053..518178 (+)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
MMH06_RS02735 (IONPJBJN_00535)	comD/comD1	518199..519524 (+)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
MMH06_RS02740 (IONPJBJN_00536)	comE	519521..520273 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
MMH06_RS02755 (IONPJBJN_00539)	-	520516..521058 (-)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
MMH06_RS10895	-	521165..522312 (+)	1148	Protein_546	YhgE/Pip family protein	-
MMH06_RS02770 (IONPJBJN_00541)	-	522342..524894 (-)	2553	WP_000834680.1	YfhO family protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1152074 MMH06_RS02740 WP_000866065.1 519521..520273(+) (comE) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1152074 MMH06_RS02740 WP_000866065.1 519521..520273(+) (comE) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408