Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   DQK99_RS11620 Genome accession   NZ_LS483448
Coordinates   2126069..2126821 (-) Length   250 a.a.
NCBI ID   WP_000866065.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 4041STDY6836167     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2121069..2131821
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQK99_RS12700 - 2123502..2125105 (-) 1604 Protein_2154 YhgE/Pip family protein -
  DQK99_RS11605 - 2125284..2125826 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  DQK99_RS11620 comE 2126069..2126821 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  DQK99_RS11625 comD/comD1 2126818..2128143 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  DQK99_RS11630 comC/comC1 2128164..2128289 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  DQK99_RS11640 rlmH 2128571..2129050 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DQK99_RS11645 htrA 2129233..2130414 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  DQK99_RS11650 spo0J 2130472..2131230 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29958.31 Da        Isoelectric Point: 6.5073

>NTDB_id=1141869 DQK99_RS11620 WP_000866065.1 2126069..2126821(-) (comE) [Streptococcus pneumoniae strain 4041STDY6836167]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=1141869 DQK99_RS11620 WP_000866065.1 2126069..2126821(-) (comE) [Streptococcus pneumoniae strain 4041STDY6836167]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAAGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

100

100

1
  comE Streptococcus pneumoniae D39

100

100

1
  comE Streptococcus pneumoniae R6

100

100

1
  comE Streptococcus pneumoniae TIGR4

100

100

1
  comE Streptococcus mitis SK321

99.2

100

0.992
  comE Streptococcus mitis NCTC 12261

98.4

100

0.984
  comE Streptococcus infantis strain Atu-4

91.2

100

0.912
  comE/comE2 Streptococcus gordonii strain NCTC7865

62.8

100

0.628
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

62.8

100

0.628
  comE/blpR Streptococcus mutans UA159

41.296

98.8

0.408

Multiple sequence alignment