Detailed information NTG1141872

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQK99_RS11645
• Genome accession: NZ_LS483448
• Coordinates: 2129233..2130414 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681598.1
• Uniprot ID: A0A0B7M448
• Organism: Streptococcus pneumoniae strain 4041STDY6836167
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2124233..2135414

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQK99_RS11605	-	2125284..2125826 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
DQK99_RS11620	comE	2126069..2126821 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
DQK99_RS11625	comD/comD1	2126818..2128143 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
DQK99_RS11630	comC/comC1	2128164..2128289 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
DQK99_RS11640	rlmH	2128571..2129050 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQK99_RS11645	htrA	2129233..2130414 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
DQK99_RS11650	spo0J	2130472..2131230 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41827.69 Da
• Isoelectric Point: 6.8902

>NTDB_id=1141872 DQK99_RS11645 WP_000681598.1 2129233..2130414(+) (htrA) [Streptococcus pneumoniae strain 4041STDY6836167]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1141872 DQK99_RS11645 WP_000681598.1 2129233..2130414(+) (htrA) [Streptococcus pneumoniae strain 4041STDY6836167]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7M448

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.746	100	0.997
htrA	Streptococcus pneumoniae D39	99.746	100	0.997
htrA	Streptococcus pneumoniae R6	99.746	100	0.997
htrA	Streptococcus pneumoniae TIGR4	99.746	100	0.997
htrA	Streptococcus mitis NCTC 12261	97.455	100	0.975
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.822	100	0.55