Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQN57_RS08755 Genome accession   NZ_LS483415
Coordinates   1705768..1707039 (-) Length   423 a.a.
NCBI ID   WP_111705838.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8304     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1696049..1723758 1705768..1707039 within 0


Gene organization within MGE regions


Location: 1696049..1723758
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN57_RS08705 (NCTC8304_01724) nrdG 1696049..1696663 (-) 615 WP_111705833.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  DQN57_RS08710 (NCTC8304_01725) - 1696663..1697172 (-) 510 WP_002991345.1 GNAT family N-acetyltransferase -
  DQN57_RS08715 (NCTC8304_01726) - 1697181..1698116 (-) 936 WP_002992828.1 Gfo/Idh/MocA family protein -
  DQN57_RS09280 (NCTC8304_01727) - 1698145..1698291 (-) 147 WP_002982210.1 hypothetical protein -
  DQN57_RS08720 (NCTC8304_01728) nrdD 1698473..1700671 (-) 2199 WP_111705834.1 anaerobic ribonucleoside-triphosphate reductase -
  DQN57_RS08725 (NCTC8304_01729) - 1700768..1702327 (-) 1560 WP_111705835.1 DUF2079 domain-containing protein -
  DQN57_RS08730 (NCTC8304_01731) - 1702740..1703045 (-) 306 WP_111705836.1 DUF1292 domain-containing protein -
  DQN57_RS08735 (NCTC8304_01732) ruvX 1703057..1703476 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DQN57_RS08740 (NCTC8304_01733) - 1703473..1703742 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DQN57_RS08745 (NCTC8304_01734) spx 1703855..1704253 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DQN57_RS08750 (NCTC8304_01735) recA 1704543..1705679 (-) 1137 WP_111705837.1 recombinase RecA Machinery gene
  DQN57_RS08755 (NCTC8304_01736) cinA 1705768..1707039 (-) 1272 WP_111705838.1 competence/damage-inducible protein A Machinery gene
  DQN57_RS08760 (NCTC8304_01737) - 1707108..1707668 (-) 561 WP_030127533.1 DNA-3-methyladenine glycosylase I -
  DQN57_RS08765 (NCTC8304_01738) ruvA 1707678..1708274 (-) 597 WP_002991359.1 Holliday junction branch migration protein RuvA -
  DQN57_RS08770 (NCTC8304_01739) - 1708276..1709496 (-) 1221 WP_014612636.1 MDR family MFS transporter -
  DQN57_RS08775 (NCTC8304_01740) mutL 1709507..1711489 (-) 1983 WP_011018317.1 DNA mismatch repair endonuclease MutL -
  DQN57_RS08780 (NCTC8304_01741) - 1711584..1712729 (-) 1146 WP_021775554.1 tyrosine-type recombinase/integrase -
  DQN57_RS08790 (NCTC8304_01742) - 1713362..1714189 (-) 828 WP_014411910.1 hypothetical protein -
  DQN57_RS09285 - 1714221..1714370 (+) 150 WP_154079230.1 hypothetical protein -
  DQN57_RS08795 (NCTC8304_01743) - 1714596..1715387 (-) 792 WP_014411911.1 helix-turn-helix domain-containing protein -
  DQN57_RS08800 (NCTC8304_01744) - 1715542..1715712 (+) 171 WP_032467166.1 helix-turn-helix transcriptional regulator -
  DQN57_RS08805 (NCTC8304_01745) - 1715767..1716174 (+) 408 WP_011185070.1 hypothetical protein -
  DQN57_RS08810 (NCTC8304_01746) - 1716188..1716805 (+) 618 WP_023080068.1 Rha family transcriptional regulator -
  DQN57_RS08815 (NCTC8304_01747) - 1717051..1717383 (+) 333 WP_111681407.1 hypothetical protein -
  DQN57_RS08820 (NCTC8304_01748) - 1717380..1717601 (+) 222 WP_111705839.1 hypothetical protein -
  DQN57_RS08825 (NCTC8304_01749) - 1717604..1717795 (+) 192 WP_111681408.1 hypothetical protein -
  DQN57_RS08830 (NCTC8304_01750) - 1717807..1718136 (+) 330 WP_111705840.1 hypothetical protein -
  DQN57_RS08835 (NCTC8304_01751) - 1718139..1718411 (+) 273 WP_001100459.1 hypothetical protein -
  DQN57_RS08840 (NCTC8304_01752) - 1718412..1719269 (+) 858 WP_111705841.1 primase alpha helix C-terminal domain-containing protein -
  DQN57_RS08845 (NCTC8304_01753) - 1719238..1720926 (+) 1689 WP_002992487.1 DNA primase family protein -
  DQN57_RS08850 (NCTC8304_01754) - 1721213..1721386 (+) 174 WP_000694577.1 hypothetical protein -
  DQN57_RS09290 (NCTC8304_01755) - 1721392..1721565 (+) 174 WP_014407944.1 hypothetical protein -
  DQN57_RS08855 (NCTC8304_01756) - 1721567..1722076 (+) 510 WP_023611171.1 hypothetical protein -
  DQN57_RS08860 (NCTC8304_01757) - 1722150..1722638 (+) 489 WP_002992480.1 hypothetical protein -
  DQN57_RS08865 (NCTC8304_01758) - 1723038..1723400 (+) 363 WP_032461242.1 DUF1492 domain-containing protein -
  DQN57_RS08870 (NCTC8304_01759) - 1723375..1723758 (+) 384 WP_111677542.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46049.82 Da        Isoelectric Point: 4.9060

>NTDB_id=1140840 DQN57_RS08755 WP_111705838.1 1705768..1707039(-) (cinA) [Streptococcus pyogenes strain NCTC8304]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASHRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFICLATQNKIESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1140840 DQN57_RS08755 WP_111705838.1 1705768..1707039(-) (cinA) [Streptococcus pyogenes strain NCTC8304]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCATCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GCTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTTGCCTTGCCACTCAAAATAAGATAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.305

98.582

0.683
  cinA Streptococcus mitis NCTC 12261

68.825

98.582

0.678
  cinA Streptococcus pneumoniae TIGR4

67.866

98.582

0.669
  cinA Streptococcus pneumoniae Rx1

67.866

98.582

0.669
  cinA Streptococcus pneumoniae R6

67.866

98.582

0.669
  cinA Streptococcus pneumoniae D39

67.626

98.582

0.667
  cinA Streptococcus suis isolate S10

53.365

98.345

0.525
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment