Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   DQN57_RS00670 Genome accession   NZ_LS483415
Coordinates   103061..103999 (+) Length   312 a.a.
NCBI ID   WP_002987773.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8304     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 98061..108999
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN57_RS00660 (NCTC8304_00132) rpoC 98810..102451 (+) 3642 WP_011528160.1 DNA-directed RNA polymerase subunit beta' -
  DQN57_RS00665 (NCTC8304_00133) - 102603..102968 (+) 366 WP_111705425.1 DUF1033 family protein -
  DQN57_RS00670 (NCTC8304_00134) comYA 103061..103999 (+) 939 WP_002987773.1 competence type IV pilus ATPase ComGA Machinery gene
  DQN57_RS00675 (NCTC8304_00135) comYB 103935..104969 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  DQN57_RS00680 (NCTC8304_00136) comYC 104971..105297 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  DQN57_RS00685 (NCTC8304_00137) comGD 105272..105700 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  DQN57_RS00690 (NCTC8304_00138) comGE 105657..105941 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  DQN57_RS00695 (NCTC8304_00139) comYF 105934..106368 (+) 435 WP_002986542.1 competence type IV pilus minor pilin ComGF Machinery gene
  DQN57_RS00700 (NCTC8304_00140) comGG 106352..106678 (+) 327 WP_002986539.1 competence type IV pilus minor pilin ComGG -
  DQN57_RS00705 (NCTC8304_00141) comYH 106776..107729 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  DQN57_RS00710 (NCTC8304_00142) - 107788..108984 (+) 1197 WP_002986533.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35046.30 Da        Isoelectric Point: 8.5799

>NTDB_id=1140790 DQN57_RS00670 WP_002987773.1 103061..103999(+) (comYA) [Streptococcus pyogenes strain NCTC8304]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISSYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGITKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=1140790 DQN57_RS00670 WP_002987773.1 103061..103999(+) (comYA) [Streptococcus pyogenes strain NCTC8304]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAAGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAGTTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAAATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTATAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.736

99.679

0.615
  comYA Streptococcus mutans UA140

61.736

99.679

0.615
  comYA Streptococcus gordonii str. Challis substr. CH1

60.45

99.679

0.603
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.323

99.359

0.599
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.486

99.679

0.593
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.842

99.679

0.587
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

40

92.949

0.372

Multiple sequence alignment