Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   DQM81_RS00660 Genome accession   NZ_LS483389
Coordinates   101342..102280 (+) Length   312 a.a.
NCBI ID   WP_111688216.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10879     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 96342..107280
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM81_RS00650 (NCTC10879_00131) rpoC 97091..100732 (+) 3642 WP_030126920.1 DNA-directed RNA polymerase subunit beta' -
  DQM81_RS00655 (NCTC10879_00132) - 100884..101249 (+) 366 WP_038433847.1 DUF1033 family protein -
  DQM81_RS00660 (NCTC10879_00133) comYA 101342..102280 (+) 939 WP_111688216.1 competence type IV pilus ATPase ComGA Machinery gene
  DQM81_RS00665 (NCTC10879_00134) comYB 102216..103250 (+) 1035 WP_227868709.1 competence type IV pilus assembly protein ComGB Machinery gene
  DQM81_RS00670 (NCTC10879_00135) comYC 103252..103578 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  DQM81_RS00675 (NCTC10879_00136) comGD 103553..103981 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  DQM81_RS00680 (NCTC10879_00137) comGE 103938..104222 (+) 285 WP_011284422.1 competence type IV pilus minor pilin ComGE -
  DQM81_RS00685 (NCTC10879_00138) comYF 104215..104649 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  DQM81_RS00690 (NCTC10879_00139) comGG 104633..104959 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  DQM81_RS00695 (NCTC10879_00140) comYH 105057..106010 (+) 954 WP_038433850.1 class I SAM-dependent methyltransferase Machinery gene
  DQM81_RS00700 (NCTC10879_00141) - 106069..107265 (+) 1197 WP_010921803.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35092.37 Da        Isoelectric Point: 9.1037

>NTDB_id=1139828 DQM81_RS00660 WP_111688216.1 101342..102280(+) (comYA) [Streptococcus pyogenes strain NCTC10879]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQKA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLFEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=1139828 DQM81_RS00660 WP_111688216.1 101342..102280(+) (comYA) [Streptococcus pyogenes strain NCTC10879]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTTGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAAGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAAAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTTTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA140

62.058

99.679

0.619
  comYA Streptococcus mutans UA159

62.058

99.679

0.619
  comYA Streptococcus gordonii str. Challis substr. CH1

60.45

99.679

0.603
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.323

99.359

0.599
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.521

99.679

0.583
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369

Multiple sequence alignment