Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQM69_RS10055 Genome accession   NZ_LS483381
Coordinates   2069436..2070704 (-) Length   422 a.a.
NCBI ID   WP_019785248.1    Uniprot ID   U2KW05
Organism   Streptococcus sobrinus strain NCTC10921     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 2064436..2075704
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM69_RS10025 (NCTC10921_02003) - 2065408..2065707 (-) 300 WP_002960548.1 DUF1292 domain-containing protein -
  DQM69_RS10030 (NCTC10921_02004) ruvX 2065722..2066141 (-) 420 WP_109982787.1 Holliday junction resolvase RuvX -
  DQM69_RS10035 (NCTC10921_02005) - 2066141..2066407 (-) 267 WP_002960554.1 IreB family regulatory phosphoprotein -
  DQM69_RS10700 (NCTC10921_02006) - 2066564..2067148 (-) 585 WP_019769158.1 SP0191 family lipoprotein -
  DQM69_RS10045 (NCTC10921_02007) spx 2067378..2067776 (-) 399 WP_109982788.1 transcriptional regulator Spx -
  DQM69_RS10050 (NCTC10921_02008) recA 2068075..2069217 (-) 1143 WP_002960557.1 recombinase RecA Machinery gene
  DQM69_RS10055 (NCTC10921_02009) cinA 2069436..2070704 (-) 1269 WP_019785248.1 competence/damage-inducible protein A Machinery gene
  DQM69_RS10060 (NCTC10921_02010) - 2071215..2073128 (+) 1914 WP_019775059.1 ATP-binding cassette domain-containing protein -
  DQM69_RS10065 - 2073167..2073430 (+) 264 WP_109982789.1 hypothetical protein -
  DQM69_RS10070 (NCTC10921_02011) - 2073480..2073881 (+) 402 WP_019777428.1 helix-turn-helix domain-containing protein -
  DQM69_RS10075 (NCTC10921_02012) - 2073915..2074466 (-) 552 WP_002960562.1 DNA-3-methyladenine glycosylase I -
  DQM69_RS10080 (NCTC10921_02013) ruvA 2074635..2075225 (-) 591 WP_019769153.1 Holliday junction branch migration protein RuvA -

Sequence

Protein


Download         Length: 422 a.a.        Molecular weight: 45735.06 Da        Isoelectric Point: 4.6997

>NTDB_id=1139423 DQM69_RS10055 WP_019785248.1 2069436..2070704(-) (cinA) [Streptococcus sobrinus strain NCTC10921]
MKAEIIAVGTEILTGQIVNTNAQFLSEKFAELGIDVYFQTAVGDNEERLLSILDLARRSDMIVLCGGLGPTDDDLTKQTL
AKFLNRSLVFDDQAMDKLNRFFAARPAVLRTSNNERQAQIVEGATPLQNRTGLAVGALLEIEDKTYIVLPGPPSELKPMV
QEQLLPLIDQDHQQLYSRVLRFFGIGESQLVTILDDFIKKQTDPTIAPYAKTGEVTLRLSTKSQSQAKAEQKLDQLEAKL
LAVQSLEDRPLSSYFYAYGDDNSLAQVTFDLLKSSGKTITAAESLTAGLFQATLADFSGASNVFNGGFVTYSMEEKSKML
DIPLADLQAHGVVSAFTAEAMAAGARSKTGADIAVSLTGVAGPDSLEGQPAGTVFLGLATADSLESHLIKINGRSRSDVR
EIAVLHAFDQVRKTLLKEKNLV

Nucleotide


Download         Length: 1269 bp        

>NTDB_id=1139423 DQM69_RS10055 WP_019785248.1 2069436..2070704(-) (cinA) [Streptococcus sobrinus strain NCTC10921]
ATGAAAGCTGAAATAATTGCAGTCGGAACGGAAATTTTAACGGGGCAAATTGTCAATACCAATGCCCAATTCCTCTCGGA
AAAATTTGCCGAGTTGGGAATTGATGTCTACTTCCAGACGGCTGTTGGTGACAATGAAGAACGTCTCTTGTCAATTCTTG
ATCTAGCCCGCCGCAGCGATATGATTGTGCTCTGCGGTGGTCTTGGGCCAACGGATGATGACTTAACCAAACAAACCTTG
GCCAAATTTCTCAATCGATCCTTGGTCTTTGATGACCAGGCTATGGATAAATTGAATCGCTTCTTTGCGGCTCGTCCAGC
TGTACTTCGGACCTCCAACAATGAGCGACAGGCCCAGATTGTTGAGGGAGCTACTCCCTTGCAGAATCGGACCGGTCTAG
CAGTTGGCGCTTTGCTTGAGATAGAGGATAAGACCTATATTGTTCTGCCAGGGCCACCAAGTGAACTCAAGCCGATGGTG
CAAGAGCAGCTTCTGCCTCTGATTGACCAGGATCATCAGCAGCTATATTCCCGTGTTCTGCGTTTCTTTGGTATCGGTGA
GAGTCAGTTGGTCACAATTCTCGATGACTTCATCAAGAAGCAGACTGATCCGACCATTGCTCCTTACGCAAAGACGGGAG
AAGTTACCCTGAGACTGTCCACCAAGTCTCAGAGTCAAGCCAAAGCTGAGCAAAAATTAGACCAACTTGAAGCAAAATTG
TTGGCTGTTCAATCGCTAGAAGATCGGCCCCTATCCAGCTATTTTTATGCCTATGGAGACGATAATTCCCTAGCTCAAGT
TACTTTTGACTTGCTCAAGAGTTCTGGCAAGACAATTACGGCCGCAGAAAGTCTGACAGCAGGTCTCTTCCAAGCAACCC
TAGCGGACTTTTCTGGAGCTTCCAACGTCTTTAATGGGGGTTTTGTTACCTATAGTATGGAGGAAAAATCTAAGATGCTG
GATATTCCTCTGGCTGACCTCCAAGCTCATGGCGTGGTTTCAGCCTTTACCGCTGAAGCTATGGCCGCTGGTGCAAGAAG
CAAGACTGGTGCAGATATTGCTGTTTCCTTGACTGGGGTTGCTGGACCCGACAGCTTGGAAGGCCAACCGGCTGGAACCG
TTTTTCTTGGTTTAGCTACAGCTGACAGTTTAGAAAGTCACCTGATAAAAATAAATGGCCGCTCCCGCAGTGATGTGCGT
GAGATTGCCGTTCTACATGCCTTTGATCAAGTGCGAAAAACTTTATTAAAGGAAAAAAATTTAGTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-415)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2KW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

70.686

100

0.709
  cinA Streptococcus mitis SK321

69.69

99.289

0.692
  cinA Streptococcus mitis NCTC 12261

68.496

99.289

0.68
  cinA Streptococcus pneumoniae TIGR4

68.019

99.289

0.675
  cinA Streptococcus pneumoniae Rx1

68.019

99.289

0.675
  cinA Streptococcus pneumoniae R6

68.019

99.289

0.675
  cinA Streptococcus pneumoniae D39

67.78

99.289

0.673
  cinA Streptococcus suis isolate S10

56.01

98.578

0.552
  cinA Bacillus subtilis subsp. subtilis str. 168

45.024

100

0.45

Multiple sequence alignment