Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQL31_RS09610 Genome accession   NZ_LS483320
Coordinates   1836264..1837535 (-) Length   423 a.a.
NCBI ID   WP_111677539.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC5164     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1826542..1854240 1836264..1837535 within 0


Gene organization within MGE regions


Location: 1826542..1854240
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL31_RS09560 (NCTC5164_01909) nrdG 1826542..1827156 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  DQL31_RS09565 (NCTC5164_01910) - 1827156..1827665 (-) 510 WP_111677535.1 GNAT family N-acetyltransferase -
  DQL31_RS09570 (NCTC5164_01911) - 1827674..1828609 (-) 936 WP_111677536.1 Gfo/Idh/MocA family protein -
  DQL31_RS10200 (NCTC5164_01912) - 1828638..1828784 (-) 147 WP_002982210.1 hypothetical protein -
  DQL31_RS09575 (NCTC5164_01913) nrdD 1828966..1831164 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  DQL31_RS09580 (NCTC5164_01914) - 1831261..1832820 (-) 1560 WP_111677537.1 DUF2079 domain-containing protein -
  DQL31_RS09585 (NCTC5164_01916) - 1833234..1833539 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DQL31_RS09590 (NCTC5164_01917) ruvX 1833551..1833970 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DQL31_RS09595 (NCTC5164_01918) - 1833967..1834236 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DQL31_RS09600 (NCTC5164_01919) spx 1834350..1834748 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DQL31_RS09605 (NCTC5164_01920) recA 1835039..1836175 (-) 1137 WP_111677538.1 recombinase RecA Machinery gene
  DQL31_RS09610 (NCTC5164_01921) cinA 1836264..1837535 (-) 1272 WP_111677539.1 competence/damage-inducible protein A Machinery gene
  DQL31_RS09615 (NCTC5164_01922) - 1837604..1838164 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  DQL31_RS09620 (NCTC5164_01923) ruvA 1838174..1838770 (-) 597 WP_111677540.1 Holliday junction branch migration protein RuvA -
  DQL31_RS09625 (NCTC5164_01924) - 1838772..1839992 (-) 1221 WP_002982178.1 MDR family MFS transporter -
  DQL31_RS09630 (NCTC5164_01925) mutL 1840003..1841985 (-) 1983 WP_111677601.1 DNA mismatch repair endonuclease MutL -
  DQL31_RS09635 (NCTC5164_01926) - 1842080..1843225 (-) 1146 WP_021775554.1 tyrosine-type recombinase/integrase -
  DQL31_RS09645 (NCTC5164_01927) - 1843858..1844685 (-) 828 WP_014411910.1 hypothetical protein -
  DQL31_RS10205 - 1844717..1844866 (+) 150 WP_154079230.1 hypothetical protein -
  DQL31_RS09650 (NCTC5164_01928) - 1845092..1845883 (-) 792 WP_014411911.1 helix-turn-helix domain-containing protein -
  DQL31_RS09655 (NCTC5164_01929) - 1846038..1846208 (+) 171 WP_032467166.1 helix-turn-helix transcriptional regulator -
  DQL31_RS09660 (NCTC5164_01930) - 1846263..1846670 (+) 408 WP_002992501.1 hypothetical protein -
  DQL31_RS09665 (NCTC5164_01931) - 1846684..1847301 (+) 618 WP_111677541.1 Rha family transcriptional regulator -
  DQL31_RS09670 (NCTC5164_01932) - 1847535..1847876 (+) 342 WP_023611295.1 hypothetical protein -
  DQL31_RS09675 (NCTC5164_01933) - 1847863..1848084 (+) 222 WP_023611263.1 hypothetical protein -
  DQL31_RS09680 (NCTC5164_01934) - 1848087..1848278 (+) 192 WP_010922764.1 hypothetical protein -
  DQL31_RS09685 (NCTC5164_01935) - 1848290..1848619 (+) 330 WP_003058810.1 hypothetical protein -
  DQL31_RS09690 (NCTC5164_01936) - 1848622..1848894 (+) 273 WP_001100459.1 hypothetical protein -
  DQL31_RS09695 (NCTC5164_01937) - 1848895..1849752 (+) 858 WP_010922767.1 primase alpha helix C-terminal domain-containing protein -
  DQL31_RS09700 (NCTC5164_01938) - 1849721..1851409 (+) 1689 WP_002992487.1 DNA primase family protein -
  DQL31_RS09705 (NCTC5164_01939) - 1851696..1851869 (+) 174 WP_000694577.1 hypothetical protein -
  DQL31_RS10210 (NCTC5164_01940) - 1851875..1852048 (+) 174 WP_014407944.1 hypothetical protein -
  DQL31_RS09710 (NCTC5164_01941) - 1852050..1852559 (+) 510 WP_023611171.1 hypothetical protein -
  DQL31_RS09715 (NCTC5164_01942) - 1852633..1853121 (+) 489 WP_002992480.1 hypothetical protein -
  DQL31_RS09720 (NCTC5164_01943) - 1853520..1853882 (+) 363 WP_032461242.1 DUF1492 domain-containing protein -
  DQL31_RS09725 (NCTC5164_01944) - 1853857..1854240 (+) 384 WP_111677542.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45976.71 Da        Isoelectric Point: 4.8322

>NTDB_id=1136331 DQL31_RS09610 WP_111677539.1 1836264..1837535(-) (cinA) [Streptococcus pyogenes strain NCTC5164]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQSLADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1136331 DQL31_RS09610 WP_111677539.1 1836264..1837535(-) (cinA) [Streptococcus pyogenes strain NCTC5164]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTTTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAATCAATCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAACTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGCGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCCACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.504

100

0.695
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.345

98.582

0.674
  cinA Streptococcus pneumoniae Rx1

68.345

98.582

0.674
  cinA Streptococcus pneumoniae R6

68.345

98.582

0.674
  cinA Streptococcus pneumoniae D39

68.106

98.582

0.671
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment