Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   E0F34_RS08260 Genome accession   NZ_LR536843
Coordinates   1518388..1519092 (-) Length   234 a.a.
NCBI ID   WP_130885243.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1507257..1523339 1518388..1519092 within 0


Gene organization within MGE regions


Location: 1507257..1523339
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F34_RS08210 (SAMEA104035599_01557) - 1507257..1508027 (-) 771 WP_000229328.1 sulfite exporter TauE/SafE family protein -
  E0F34_RS08215 (SAMEA104035599_01558) - 1508042..1508890 (-) 849 WP_000782429.1 formylglycine-generating enzyme family protein -
  E0F34_RS08220 (SAMEA104035599_01559) - 1508887..1510362 (-) 1476 WP_000250870.1 arylsulfatase -
  E0F34_RS08225 (SAMEA104035599_01560) - 1510685..1512040 (-) 1356 WP_001094994.1 PTS sugar transporter subunit IIC -
  E0F34_RS08230 (SAMEA104035599_01561) - 1512050..1512367 (-) 318 WP_001005887.1 PTS lactose/cellobiose transporter subunit IIA -
  E0F34_RS08235 (SAMEA104035599_01562) - 1512384..1512701 (-) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  E0F34_RS08240 (SAMEA104035599_01563) - 1512714..1514399 (-) 1686 WP_001844953.1 family 16 glycosylhydrolase -
  E0F34_RS08245 (SAMEA104035599_01564) - 1514404..1515300 (-) 897 WP_000825669.1 PEP phosphonomutase -
  E0F34_RS08250 (SAMEA104035599_01565) - 1515303..1516565 (-) 1263 WP_000413336.1 PTS sugar transporter subunit IIC -
  E0F34_RS08255 (SAMEA104035599_01566) - 1516845..1518023 (+) 1179 WP_000175881.1 ROK family transcriptional regulator -
  E0F34_RS08260 (SAMEA104035599_01567) comE 1518388..1519092 (-) 705 WP_130885243.1 competence system response regulator transcription factor ComE Regulator
  E0F34_RS08265 (SAMEA104035599_01568) comD 1519089..1520075 (-) 987 Protein_1563 competence system sensor histidine kinase ComD -
  E0F34_RS08270 (SAMEA104035599_01569) - 1520334..1521287 (+) 954 WP_001155321.1 IS30-like element ISSpn8 family transposase -
  E0F34_RS08280 (SAMEA104035599_01570) - 1521692..1522168 (-) 477 WP_061650030.1 hypothetical protein -
  E0F34_RS08285 (SAMEA104035599_01571) - 1522631..1522900 (-) 270 WP_130897118.1 hypothetical protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 28007.87 Da        Isoelectric Point: 5.4136

>NTDB_id=1126564 E0F34_RS08260 WP_130885243.1 1518388..1519092(-) (comE) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISR

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1126564 E0F34_RS08260 WP_130885243.1 1518388..1519092(-) (comE) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-234)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

100

100

1
  comE Streptococcus pneumoniae D39

100

100

1
  comE Streptococcus pneumoniae R6

100

100

1
  comE Streptococcus pneumoniae TIGR4

100

100

1
  comE Streptococcus mitis SK321

99.145

100

0.991
  comE Streptococcus mitis NCTC 12261

98.291

100

0.983
  comE Streptococcus infantis strain Atu-4

91.88

100

0.919
  comE/comE2 Streptococcus gordonii strain NCTC7865

63.248

100

0.632
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

63.248

100

0.632
  comE/blpR Streptococcus mutans UA159

41.772

100

0.423
  comE/comE2 Streptococcus equinus JB1

35.391

100

0.368

Multiple sequence alignment