Detailed information NTG1126385

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: E0F40_RS11310
• Genome accession: NZ_LR216065
• Coordinates: 2101125..2101877 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2096125..2106877

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F40_RS12530	-	2098558..2100161 (-)	1604	Protein_2108	YhgE/Pip family protein	-
E0F40_RS11295 (SAMEA3714487_02151)	-	2100340..2100882 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
E0F40_RS11310 (SAMEA3714487_02154)	comE	2101125..2101877 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
E0F40_RS11315 (SAMEA3714487_02155)	comD/comD1	2101874..2103199 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
E0F40_RS11320 (SAMEA3714487_02156)	comC/comC1	2103220..2103345 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
E0F40_RS11330 (SAMEA3714487_02158)	rlmH	2103627..2104106 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
E0F40_RS11335 (SAMEA3714487_02159)	htrA	2104289..2105470 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
E0F40_RS11340 (SAMEA3714487_02160)	spo0J	2105528..2106286 (+)	759	WP_000410381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1126385 E0F40_RS11310 WP_000866065.1 2101125..2101877(-) (comE) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1126385 E0F40_RS11310 WP_000866065.1 2101125..2101877(-) (comE) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408