Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   E0F40_RS11320 Genome accession   NZ_LR216065
Coordinates   2103220..2103345 (-) Length   41 a.a.
NCBI ID   WP_000799689.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2098220..2108345
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F40_RS12530 - 2098558..2100161 (-) 1604 Protein_2108 YhgE/Pip family protein -
  E0F40_RS11295 (SAMEA3714487_02151) - 2100340..2100882 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  E0F40_RS11310 (SAMEA3714487_02154) comE 2101125..2101877 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  E0F40_RS11315 (SAMEA3714487_02155) comD/comD1 2101874..2103199 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  E0F40_RS11320 (SAMEA3714487_02156) comC/comC1 2103220..2103345 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  E0F40_RS11330 (SAMEA3714487_02158) rlmH 2103627..2104106 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  E0F40_RS11335 (SAMEA3714487_02159) htrA 2104289..2105470 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  E0F40_RS11340 (SAMEA3714487_02160) spo0J 2105528..2106286 (+) 759 WP_000410381.1 ParB/RepB/Spo0J family partition protein Regulator
  E0F40_RS11345 (SAMEA3714487_02161) dnaA 2106499..2107860 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4971.00 Da        Isoelectric Point: 11.0775

>NTDB_id=1126387 E0F40_RS11320 WP_000799689.1 2103220..2103345(-) (comC/comC1) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=1126387 E0F40_RS11320 WP_000799689.1 2103220..2103345(-) (comC/comC1) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GTTGTCAAAATTCTTCCGTGATTTTATTTTACAAAGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

100

100

1
  comC/comC1 Streptococcus pneumoniae G54

100

100

1
  comC/comC1 Streptococcus pneumoniae D39

100

100

1
  comC/comC1 Streptococcus pneumoniae Rx1

100

100

1
  comC/comC2 Streptococcus pneumoniae A66

80.488

100

0.805
  comC/comC2 Streptococcus pneumoniae TIGR4

80.488

100

0.805
  comC Streptococcus mitis SK321

78.049

100

0.78
  comC Streptococcus mitis NCTC 12261

74.074

65.854

0.488
  comC/blpC Streptococcus mutans UA159

44.444

87.805

0.39

Multiple sequence alignment