Detailed information NTG1116238

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQB41_RS11675
• Genome accession: NZ_LR129840
• Coordinates: 2163897..2164649 (-)
• Length: 250 a.a.
• NCBI ID: WP_050975290.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 4496 isolate 4496
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2158897..2169649

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQB41_RS12120	-	2159910..2161257 (-)	1348	Protein_2163	IS3 family transposase	-
EQB41_RS12800	-	2161330..2162984 (-)	1655	Protein_2164	YhgE/Pip family protein	-
EQB41_RS11660	-	2163112..2163654 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQB41_RS11675	comE	2163897..2164649 (-)	753	WP_050975290.1	competence system response regulator transcription factor ComE	Regulator
EQB41_RS11680	comD/comD1	2164646..2165971 (-)	1326	WP_127820882.1	competence system sensor histidine kinase ComD	Regulator
EQB41_RS11685	comC/comC1	2165992..2166117 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQB41_RS11695	rlmH	2166399..2166878 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQB41_RS11700	htrA	2167061..2168242 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
EQB41_RS11705	spo0J	2168300..2169058 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29974.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1116238 EQB41_RS11675 WP_050975290.1 2163897..2164649(-) (comE) [Streptococcus pneumoniae strain 4496 isolate 4496]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFSKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1116238 EQB41_RS11675 WP_050975290.1 2163897..2164649(-) (comE) [Streptococcus pneumoniae strain 4496 isolate 4496]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATTTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTTCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98	100	0.98
comE	Streptococcus infantis strain Atu-4	90.8	100	0.908
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408