Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   EQB41_RS11680 Genome accession   NZ_LR129840
Coordinates   2164646..2165971 (-) Length   441 a.a.
NCBI ID   WP_127820882.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 4496 isolate 4496     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2159646..2170971
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB41_RS12120 - 2159910..2161257 (-) 1348 Protein_2163 IS3 family transposase -
  EQB41_RS12800 - 2161330..2162984 (-) 1655 Protein_2164 YhgE/Pip family protein -
  EQB41_RS11660 - 2163112..2163654 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  EQB41_RS11675 comE 2163897..2164649 (-) 753 WP_050975290.1 competence system response regulator transcription factor ComE Regulator
  EQB41_RS11680 comD/comD1 2164646..2165971 (-) 1326 WP_127820882.1 competence system sensor histidine kinase ComD Regulator
  EQB41_RS11685 comC/comC1 2165992..2166117 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  EQB41_RS11695 rlmH 2166399..2166878 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQB41_RS11700 htrA 2167061..2168242 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  EQB41_RS11705 spo0J 2168300..2169058 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51277.76 Da        Isoelectric Point: 6.7802

>NTDB_id=1116239 EQB41_RS11680 WP_127820882.1 2164646..2165971(-) (comD/comD1) [Streptococcus pneumoniae strain 4496 isolate 4496]
MDLFGFGTVIVHFLIISHSYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKER
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=1116239 EQB41_RS11680 WP_127820882.1 2164646..2165971(-) (comD/comD1) [Streptococcus pneumoniae strain 4496 isolate 4496]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGCTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGAAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

98.866

100

0.989
  comD/comD1 Streptococcus pneumoniae D39

98.866

100

0.989
  comD/comD1 Streptococcus pneumoniae R6

98.866

100

0.989
  comD/comD2 Streptococcus pneumoniae TIGR4

96.599

100

0.966
  comD Streptococcus mitis SK321

92.29

100

0.923
  comD Streptococcus mitis NCTC 12261

86.168

100

0.862
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.198

84.807

0.417
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.936

85.261

0.417

Multiple sequence alignment