Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   EQB41_RS10035 Genome accession   NZ_LR129840
Coordinates   1855627..1856883 (-) Length   418 a.a.
NCBI ID   WP_000642707.1    Uniprot ID   A0A0B7L5W3
Organism   Streptococcus pneumoniae strain 4496 isolate 4496     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1850627..1861883
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB41_RS10005 - 1850684..1850890 (-) 207 WP_000366085.1 hypothetical protein -
  EQB41_RS10010 - 1850877..1851038 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  EQB41_RS10015 lytA 1851397..1852353 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  EQB41_RS10020 - 1852729..1854099 (-) 1371 WP_001036295.1 MATE family efflux transporter -
  EQB41_RS10030 recA 1854406..1855572 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  EQB41_RS10035 cinA 1855627..1856883 (-) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  EQB41_RS10040 brpA 1856968..1857984 (-) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  EQB41_RS10045 - 1857992..1858510 (-) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  EQB41_RS10050 tsaE 1858500..1858943 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  EQB41_RS10055 comM 1859029..1859649 (-) 621 WP_000839908.1 hypothetical protein Regulator
  EQB41_RS10065 - 1860032..1860895 (-) 864 WP_050199571.1 helix-turn-helix domain-containing protein -
  EQB41_RS10070 - 1861084..1861254 (+) 171 WP_000742180.1 PhrA family quorum-sensing system peptide -
  EQB41_RS10075 - 1861569..1861865 (+) 297 Protein_1892 lactococcin 972 family bacteriocin -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45061.46 Da        Isoelectric Point: 4.6027

>NTDB_id=1116216 EQB41_RS10035 WP_000642707.1 1855627..1856883(-) (cinA) [Streptococcus pneumoniae strain 4496 isolate 4496]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=1116216 EQB41_RS10035 WP_000642707.1 1855627..1856883(-) (cinA) [Streptococcus pneumoniae strain 4496 isolate 4496]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGCTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L5W3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.761

100

0.998
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.78

100

0.938
  cinA Streptococcus mitis NCTC 12261

93.541

100

0.935
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment