Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   A66_RS00005 Genome accession   NZ_LN847353
Coordinates   111..863 (-) Length   250 a.a.
NCBI ID   WP_053039410.1    Uniprot ID   Q9LB21
Organism   Streptococcus pneumoniae strain A66     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1..5863
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A66_RS00005 (A66_00001) comE 111..863 (-) 753 WP_053039410.1 competence system response regulator transcription factor ComE Regulator
  A66_RS00010 (A66_00002) comD/comD2 860..2185 (-) 1326 WP_000364846.1 competence system sensor histidine kinase ComD Regulator
  A66_RS00015 (A66_00003) comC/comC2 2206..2331 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  A66_RS00025 (A66_00004) rlmH 2613..3092 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  A66_RS00030 (A66_00005) htrA 3275..4456 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  A66_RS00035 (A66_00006) spo0J 4514..5272 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29859.17 Da        Isoelectric Point: 6.3126

>NTDB_id=1114543 A66_RS00005 WP_053039410.1 111..863(-) (comE) [Streptococcus pneumoniae strain A66]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIGKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=1114543 A66_RS00005 WP_053039410.1 111..863(-) (comE) [Streptococcus pneumoniae strain A66]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTGGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-121)

LytTr DNA-binding domain (LytTR)

(151-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9LB21

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

99.6

100

0.996
  comE Streptococcus pneumoniae D39

99.6

100

0.996
  comE Streptococcus pneumoniae R6

99.6

100

0.996
  comE Streptococcus pneumoniae TIGR4

99.6

100

0.996
  comE Streptococcus mitis SK321

98.8

100

0.988
  comE Streptococcus mitis NCTC 12261

98

100

0.98
  comE Streptococcus infantis strain Atu-4

90.8

100

0.908
  comE/comE2 Streptococcus gordonii strain NCTC7865

62.4

100

0.624
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

62.4

100

0.624
  comE/blpR Streptococcus mutans UA159

41.296

98.8

0.408

Multiple sequence alignment