Detailed information NTG1114356

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AT689_RS02700
• Genome accession: NZ_LN831051
• Coordinates: 501795..502547 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain NCTC7465
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 496795..507547

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AT689_RS02670 (ERS445053_00527)	spo0J	497386..498144 (-)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator
AT689_RS02675 (ERS445053_00528)	htrA	498202..499383 (-)	1182	WP_000681597.1	S1C family serine protease	Regulator
AT689_RS02680 (ERS445053_00529)	rlmH	499566..500045 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AT689_RS02690 (ERS445053_00531)	comC/comC1	500327..500452 (+)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AT689_RS02695 (ERS445053_00532)	comD/comD1	500473..501798 (+)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
AT689_RS02700 (ERS445053_00533)	comE	501795..502547 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AT689_RS02715 (ERS445053_00536)	-	502790..503332 (-)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AT689_RS13650	-	503511..505114 (+)	1604	Protein_536	YhgE/Pip family protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1114356 AT689_RS02700 WP_000866065.1 501795..502547(+) (comE) [Streptococcus pneumoniae strain NCTC7465]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1114356 AT689_RS02700 WP_000866065.1 501795..502547(+) (comE) [Streptococcus pneumoniae strain NCTC7465]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408