Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ACI5K2_RS04255 Genome accession   NZ_CP174089
Coordinates   892814..894055 (+) Length   413 a.a.
NCBI ID   WP_014569352.1    Uniprot ID   -
Organism   Lacticaseibacillus rhamnosus strain 484     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 884898..933785 892814..894055 within 0


Gene organization within MGE regions


Location: 884898..933785
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACI5K2_RS04225 (ACI5K2_04225) - 885396..887696 (+) 2301 WP_014569347.1 DNA translocase FtsK -
  ACI5K2_RS04230 (ACI5K2_04230) yfmF 887705..888967 (+) 1263 WP_014569348.1 EF-P 5-aminopentanol modification-associated protein YfmF -
  ACI5K2_RS04235 (ACI5K2_04235) yfmH 888964..890256 (+) 1293 WP_014569349.1 EF-P 5-aminopentanol modification-associated protein YfmH -
  ACI5K2_RS04240 (ACI5K2_04240) ymfI 890256..890984 (+) 729 WP_014569350.1 elongation factor P 5-aminopentanone reductase -
  ACI5K2_RS04245 (ACI5K2_04245) - 891071..892006 (+) 936 WP_005688668.1 helix-turn-helix domain-containing protein -
  ACI5K2_RS04250 (ACI5K2_04250) pgsA 892003..892593 (+) 591 WP_014569351.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  ACI5K2_RS04255 (ACI5K2_04255) cinA 892814..894055 (+) 1242 WP_014569352.1 competence/damage-inducible protein A Machinery gene
  ACI5K2_RS04260 (ACI5K2_04260) recA 894107..895159 (+) 1053 WP_005688187.1 recombinase RecA Machinery gene
  ACI5K2_RS04265 (ACI5K2_04265) rny 895784..897355 (+) 1572 WP_005684479.1 ribonuclease Y -
  ACI5K2_RS04270 (ACI5K2_04270) - 897444..898100 (-) 657 WP_029943817.1 YigZ family protein -
  ACI5K2_RS04275 (ACI5K2_04275) - 898128..899393 (+) 1266 WP_014569356.1 DEAD/DEAH box helicase -
  ACI5K2_RS04280 (ACI5K2_04280) - 899552..900070 (+) 519 WP_005688681.1 ComF family protein -
  ACI5K2_RS04285 (ACI5K2_04285) hpf 900262..900819 (+) 558 WP_005684485.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  ACI5K2_RS04290 (ACI5K2_04290) secA 901402..903765 (+) 2364 WP_005684487.1 preprotein translocase subunit SecA -
  ACI5K2_RS04295 (ACI5K2_04295) prfB 903907..905023 (+) 1117 WP_154241369.1 peptide chain release factor 2 -
  ACI5K2_RS04300 (ACI5K2_04300) ftsE 905100..905786 (+) 687 WP_005684489.1 cell division ATP-binding protein FtsE -
  ACI5K2_RS04305 (ACI5K2_04305) ftsX 905776..906663 (+) 888 WP_005684490.1 permease-like cell division protein FtsX -
  ACI5K2_RS04310 (ACI5K2_04310) - 906741..906878 (+) 138 WP_014569359.1 hypothetical protein -
  ACI5K2_RS04315 (ACI5K2_04315) - 906934..908031 (+) 1098 WP_014569360.1 PDZ domain-containing protein -
  ACI5K2_RS04320 (ACI5K2_04320) - 908028..908732 (+) 705 WP_005688690.1 response regulator transcription factor -
  ACI5K2_RS04325 (ACI5K2_04325) pnpS 908725..910392 (+) 1668 WP_014569361.1 two-component system histidine kinase PnpS -
  ACI5K2_RS04330 (ACI5K2_04330) - 910482..911348 (+) 867 WP_005684496.1 phosphate ABC transporter substrate-binding protein PstS family protein -
  ACI5K2_RS04335 (ACI5K2_04335) pstC 911496..912419 (+) 924 WP_005684497.1 phosphate ABC transporter permease subunit PstC -
  ACI5K2_RS04340 (ACI5K2_04340) pstA 912416..913300 (+) 885 WP_005684499.1 phosphate ABC transporter permease PstA -
  ACI5K2_RS04345 (ACI5K2_04345) pstB 913371..914189 (+) 819 WP_005713669.1 phosphate ABC transporter ATP-binding protein PstB -
  ACI5K2_RS04350 (ACI5K2_04350) pstB 914199..914963 (+) 765 WP_005684501.1 phosphate ABC transporter ATP-binding protein PstB -
  ACI5K2_RS04355 (ACI5K2_04355) phoU 914974..915651 (+) 678 WP_005684502.1 phosphate signaling complex protein PhoU -
  ACI5K2_RS04360 (ACI5K2_04360) - 915905..916783 (-) 879 WP_048653158.1 IS3 family transposase -
  ACI5K2_RS04365 (ACI5K2_04365) - 916780..917508 (-) 729 WP_014569363.1 helix-turn-helix domain-containing protein -
  ACI5K2_RS04370 (ACI5K2_04370) liaX 918077..919567 (+) 1491 WP_014569364.1 daptomycin-sensing surface protein LiaX -
  ACI5K2_RS04375 (ACI5K2_04375) - 919579..919839 (+) 261 WP_005688700.1 hypothetical protein -
  ACI5K2_RS04380 (ACI5K2_04380) - 919842..920177 (+) 336 WP_005684507.1 phage holin family protein -
  ACI5K2_RS04385 (ACI5K2_04385) hprK 920444..921403 (+) 960 WP_005684508.1 HPr(Ser) kinase/phosphatase -
  ACI5K2_RS04390 (ACI5K2_04390) lgt 921405..922232 (+) 828 WP_014569365.1 prolipoprotein diacylglyceryl transferase -
  ACI5K2_RS04395 (ACI5K2_04395) - 922243..923298 (+) 1056 WP_014569366.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  ACI5K2_RS04400 (ACI5K2_04400) trxB 923364..924311 (+) 948 WP_005684511.1 thioredoxin-disulfide reductase -
  ACI5K2_RS04405 (ACI5K2_04405) - 924563..926290 (+) 1728 WP_014569367.1 phospho-sugar mutase -
  ACI5K2_RS04410 (ACI5K2_04410) - 926750..927397 (+) 648 WP_014569368.1 YfbR-like 5'-deoxynucleotidase -
  ACI5K2_RS04415 (ACI5K2_04415) uvrB 927668..929683 (+) 2016 WP_005688715.1 excinuclease ABC subunit UvrB -
  ACI5K2_RS04420 (ACI5K2_04420) uvrA 929864..932758 (+) 2895 WP_014569369.1 excinuclease ABC subunit UvrA -
  ACI5K2_RS04425 (ACI5K2_04425) - 932960..933499 (+) 540 WP_014569370.1 HdeD family acid-resistance protein -

Sequence

Protein


Download         Length: 413 a.a.        Molecular weight: 44472.12 Da        Isoelectric Point: 7.2504

>NTDB_id=1074150 ACI5K2_RS04255 WP_014569352.1 892814..894055(+) (cinA) [Lacticaseibacillus rhamnosus strain 484]
MQAEIIAIGTEILMGQITNTNGAYMAKQLATLGIASYHQQVVGDNAKRLADAISLAEQRSDIVILIGGLGPTPDDLTKQT
LAAHLNLPLVEDADAMAKLAARVKQQQRPMTPNNRLQAMYPQGAIVLANRVGLAVGAWVEQRQHAYVLLPGPPKEFVPMV
DHELLPRLAKYSGHQEVLESRVMRFFGIGESQLVTDLSDLIANQTNPTLATYIKDHEVTVRVTASGKTQAEAAAKLEPMI
GIIMDREGRYFYGYGDDNSLAQELVKALAASDKQISAAESLTAGAFQAALGDVPGVSAYFKGGFVTYALATKAAFLNIDA
RQLSEHGVVSEFTAKAMAEHARQRAAADIAVSFTGVAGPDKLEGQPAGTVWIGLARLGEKPIAQVYHFPGGRNDVRKRAV
MTGMMMVLKRLRE

Nucleotide


Download         Length: 1242 bp        

>NTDB_id=1074150 ACI5K2_RS04255 WP_014569352.1 892814..894055(+) (cinA) [Lacticaseibacillus rhamnosus strain 484]
ATGCAAGCAGAAATTATTGCTATCGGAACGGAAATTCTGATGGGACAAATTACAAATACAAATGGCGCGTATATGGCTAA
ACAACTGGCTACATTAGGTATTGCGAGCTATCATCAACAGGTTGTTGGGGATAATGCAAAACGACTGGCTGACGCGATAA
GTTTGGCGGAACAACGCAGTGATATCGTTATTTTGATTGGTGGTTTAGGACCAACACCGGATGATTTAACGAAGCAAACC
CTAGCCGCACACCTGAATTTACCCTTGGTGGAAGACGCTGACGCTATGGCCAAGTTGGCTGCGCGGGTTAAACAACAGCA
ACGTCCAATGACACCCAATAATCGCCTGCAAGCGATGTATCCCCAAGGCGCAATCGTATTGGCCAATCGTGTCGGGTTGG
CGGTCGGCGCATGGGTTGAGCAGCGCCAACACGCCTATGTTTTATTGCCGGGACCACCTAAAGAGTTTGTGCCGATGGTT
GATCATGAACTGTTGCCACGACTGGCAAAATATAGCGGGCATCAAGAAGTTTTGGAAAGTCGCGTGATGCGTTTCTTTGG
TATCGGCGAATCGCAACTTGTGACAGACTTAAGTGATTTAATTGCCAACCAGACGAATCCGACACTTGCAACTTATATAA
AAGATCATGAGGTGACAGTTCGGGTAACTGCGAGTGGCAAAACACAAGCAGAAGCCGCGGCGAAACTTGAGCCAATGATC
GGCATCATTATGGATCGTGAAGGTCGCTACTTTTACGGCTACGGTGACGATAACAGTCTTGCCCAGGAATTAGTCAAAGC
ATTGGCGGCTAGTGATAAGCAAATTAGTGCCGCTGAAAGTCTGACTGCAGGTGCATTTCAAGCGGCATTGGGAGACGTTC
CGGGAGTCTCGGCTTATTTCAAAGGCGGCTTCGTTACGTACGCTTTAGCGACAAAAGCTGCATTTTTAAATATTGATGCC
CGTCAGCTATCAGAACATGGTGTGGTGAGTGAATTTACTGCCAAAGCAATGGCAGAGCATGCTCGTCAACGAGCGGCGGC
AGACATTGCCGTTAGTTTTACCGGAGTTGCCGGTCCTGACAAGCTGGAAGGACAGCCAGCCGGCACCGTCTGGATTGGTT
TGGCGCGGTTAGGAGAGAAACCAATAGCACAAGTTTATCATTTTCCGGGTGGGCGAAATGACGTCCGCAAGCGCGCCGTT
ATGACGGGGATGATGATGGTGTTGAAGCGTTTACGCGAATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(258-410)

Damage-inducible protein CinA KH domain (CinA_KH)

(180-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

52.019

100

0.53
  cinA Streptococcus mitis NCTC 12261

52.019

100

0.53
  cinA Streptococcus pneumoniae TIGR4

51.544

100

0.525
  cinA Streptococcus pneumoniae R6

51.069

100

0.521
  cinA Streptococcus pneumoniae Rx1

51.069

100

0.521
  cinA Streptococcus mutans UA159

51.442

100

0.518
  cinA Streptococcus pneumoniae D39

50.831

100

0.518
  cinA Bacillus subtilis subsp. subtilis str. 168

44.66

99.758

0.446
  cinA Streptococcus suis isolate S10

42.593

91.525

0.39

Multiple sequence alignment