Detailed information NTG0107240

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AAA995_RS10820
• Genome accession: NZ_AP028877
• Coordinates: 2102281..2103033 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 21P20
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2097281..2108033

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA995_RS10800	-	2099714..2101317 (-)	1604	Protein_2089	YhgE/Pip domain-containing protein	-
AAA995_RS10805 (SP21P20_20980)	-	2101496..2102038 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AAA995_RS10820 (SP21P20_20990)	comE	2102281..2103033 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AAA995_RS10825 (SP21P20_21000)	comD/comD1	2103030..2104355 (-)	1326	WP_088781673.1	competence system sensor histidine kinase ComD	Regulator
AAA995_RS10830 (SP21P20_21010)	comC/comC1	2104376..2104501 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AAA995_RS10840 (SP21P20_21020)	rlmH	2104783..2105262 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AAA995_RS10845 (SP21P20_21030)	htrA	2105445..2106626 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
AAA995_RS10850 (SP21P20_21040)	spo0J	2106684..2107442 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=107240 AAA995_RS10820 WP_000866065.1 2102281..2103033(-) (comE) [Streptococcus pneumoniae strain 21P20]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=107240 AAA995_RS10820 WP_000866065.1 2102281..2103033(-) (comE) [Streptococcus pneumoniae strain 21P20]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAAGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408