Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   AAA995_RS10825 Genome accession   NZ_AP028877
Coordinates   2103030..2104355 (-) Length   441 a.a.
NCBI ID   WP_088781673.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 21P20     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2098030..2109355
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA995_RS10800 - 2099714..2101317 (-) 1604 Protein_2089 YhgE/Pip domain-containing protein -
  AAA995_RS10805 (SP21P20_20980) - 2101496..2102038 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  AAA995_RS10820 (SP21P20_20990) comE 2102281..2103033 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  AAA995_RS10825 (SP21P20_21000) comD/comD1 2103030..2104355 (-) 1326 WP_088781673.1 competence system sensor histidine kinase ComD Regulator
  AAA995_RS10830 (SP21P20_21010) comC/comC1 2104376..2104501 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  AAA995_RS10840 (SP21P20_21020) rlmH 2104783..2105262 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  AAA995_RS10845 (SP21P20_21030) htrA 2105445..2106626 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  AAA995_RS10850 (SP21P20_21040) spo0J 2106684..2107442 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51353.82 Da        Isoelectric Point: 6.7805

>NTDB_id=107241 AAA995_RS10825 WP_088781673.1 2103030..2104355(-) (comD/comD1) [Streptococcus pneumoniae strain 21P20]
MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRKIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=107241 AAA995_RS10825 WP_088781673.1 2103030..2104355(-) (comD/comD1) [Streptococcus pneumoniae strain 21P20]
ATGGATTTATTTGGATTTGGGACGGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCATTTTATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGAAAGATTTTTATTTCCTTTGGGATTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGAAAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

99.773

100

0.998
  comD/comD1 Streptococcus pneumoniae D39

99.773

100

0.998
  comD/comD1 Streptococcus pneumoniae R6

99.773

100

0.998
  comD/comD2 Streptococcus pneumoniae TIGR4

96.599

100

0.966
  comD Streptococcus mitis SK321

91.837

100

0.918
  comD Streptococcus mitis NCTC 12261

85.941

100

0.859
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419

Multiple sequence alignment