Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   ACB350_RS00665 Genome accession   NZ_CP166999
Coordinates   105376..106314 (+) Length   312 a.a.
NCBI ID   WP_030127399.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 34     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 100376..111314
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB350_RS00655 (ACB350_00655) rpoC 101124..104765 (+) 3642 WP_030127400.1 DNA-directed RNA polymerase subunit beta' -
  ACB350_RS00660 (ACB350_00660) - 104917..105282 (+) 366 WP_002986560.1 DUF1033 family protein -
  ACB350_RS00665 (ACB350_00665) comYA 105376..106314 (+) 939 WP_030127399.1 competence type IV pilus ATPase ComGA Machinery gene
  ACB350_RS00670 (ACB350_00670) comYB 106250..107284 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  ACB350_RS00675 (ACB350_00675) comYC 107286..107612 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  ACB350_RS00680 (ACB350_00680) comGD 107587..108015 (+) 429 WP_030127397.1 competence type IV pilus minor pilin ComGD -
  ACB350_RS00685 (ACB350_00685) comGE 107972..108256 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  ACB350_RS00690 (ACB350_00690) comYF 108249..108683 (+) 435 WP_002986542.1 competence type IV pilus minor pilin ComGF Machinery gene
  ACB350_RS00695 (ACB350_00695) comGG 108667..108993 (+) 327 WP_002986539.1 competence type IV pilus minor pilin ComGG -
  ACB350_RS00700 (ACB350_00700) comYH 109091..110044 (+) 954 WP_030127396.1 class I SAM-dependent methyltransferase Machinery gene
  ACB350_RS00705 (ACB350_00705) - 110103..111299 (+) 1197 WP_011888536.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35058.36 Da        Isoelectric Point: 9.1037

>NTDB_id=1036733 ACB350_RS00665 WP_030127399.1 105376..106314(+) (comYA) [Streptococcus pyogenes strain Isolate 34]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLVSHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQKA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGITKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=1036733 ACB350_RS00665 WP_030127399.1 105376..106314(+) (comYA) [Streptococcus pyogenes strain Isolate 34]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTGTTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTCAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAAAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTATAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.415

99.679

0.612
  comYA Streptococcus mutans UA140

61.415

99.679

0.612
  comYA Streptococcus gordonii str. Challis substr. CH1

60.129

99.679

0.599
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60

99.359

0.596
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.199

99.679

0.58
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

40

92.949

0.372

Multiple sequence alignment