Detailed information NTG0102208

Bioinformatically predicted

Overview

• Name: comGC
• Type: Machinery gene
• Locus tag: SMUFR_RS09120
• Genome accession: NZ_CP007016
• Coordinates: 1852652..1852966 (-)
• Length: 104 a.a.
• NCBI ID: WP_002263437.1
• Uniprot ID: Q8DS51
• Organism: Streptococcus mutans UA159-FR
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1847652..1857966

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUFR_RS09080 (SMUFR_1714)	-	1847719..1848159 (-)	441	WP_002263445.1	hypothetical protein	-
SMUFR_RS09085 (SMUFR_1715)	-	1848128..1848373 (-)	246	WP_002263444.1	helix-turn-helix transcriptional regulator	-
SMUFR_RS09090 (SMUFR_1716)	-	1848942..1850141 (-)	1200	WP_002263443.1	acetate kinase	-
SMUFR_RS09095 (SMUFR_1717)	comGH	1850200..1851153 (-)	954	WP_002263442.1	class I SAM-dependent methyltransferase	Machinery gene
SMUFR_RS09100 (SMUFR_1718)	comGG	1851208..1851597 (-)	390	WP_002263441.1	competence type IV pilus minor pilin ComGG	Machinery gene
SMUFR_RS09105 (SMUFR_1719)	comGF	1851575..1852009 (-)	435	WP_002263440.1	competence type IV pilus minor pilin ComGF	Machinery gene
SMUFR_RS09110 (SMUFR_1720)	comGE	1851996..1852289 (-)	294	WP_002263439.1	competence type IV pilus minor pilin ComGE	Machinery gene
SMUFR_RS09115 (SMUFR_1721)	comGD	1852261..1852665 (-)	405	WP_002263438.1	competence type IV pilus minor pilin ComGD	Machinery gene
SMUFR_RS09120 (SMUFR_1722)	comGC	1852652..1852966 (-)	315	WP_002263437.1	competence type IV pilus major pilin ComGC	Machinery gene
SMUFR_RS09125 (SMUFR_1723)	comGB	1852966..1853997 (-)	1032	WP_255262721.1	competence type IV pilus assembly protein ComGB	Machinery gene
SMUFR_RS09130 (SMUFR_1724)	comGA	1853933..1854874 (-)	942	WP_002263435.1	competence type IV pilus ATPase ComGA	Machinery gene
SMUFR_RS09135 (SMUFR_1725)	-	1855004..1855387 (-)	384	WP_002263434.1	DUF1033 family protein	-

Sequence

Protein

• Length: 104 a.a.
• Molecular weight: 11591.60 Da
• Isoelectric Point: 10.2206

>NTDB_id=102208 SMUFR_RS09120 WP_002263437.1 1852652..1852966(-) (comGC) [Streptococcus mutans UA159-FR]
MKKIKRVSVRAFTLIEMLVVLLIISILLLLFVPNLTKQKDKVKDTGGSAVVKVVESQAELYELNKTDSATLSKLVASGDI
TQEQANSYKDYYAKHPSKTRHVAN

Nucleotide

• Length: 315 bp

>NTDB_id=102208 SMUFR_RS09120 WP_002263437.1 1852652..1852966(-) (comGC) [Streptococcus mutans UA159-FR]
ATGAAAAAGATCAAGAGAGTCAGTGTACGGGCTTTTACGCTTATAGAAATGTTAGTAGTTCTTCTCATTATTAGTATTCT
TTTACTATTATTTGTTCCTAATTTAACTAAGCAAAAAGATAAGGTAAAAGATACTGGCGGTTCTGCCGTGGTTAAAGTTG
TAGAAAGTCAGGCTGAGCTTTATGAGCTTAATAAAACCGATTCTGCTACTCTTTCTAAATTAGTAGCTAGTGGTGATATT
ACACAAGAACAGGCAAATTCATACAAGGATTACTATGCAAAACACCCAAGTAAAACACGGCATGTCGCGAATTAA

Domains

Predicted by InterProScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (9-30)

3D structure

• AlphaFold DB: Q8DS51

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC	Streptococcus mutans UA140	100	100	1
comGC	Streptococcus mutans UA159	100	100	1
comGC	Streptococcus gordonii str. Challis substr. CH1	71.429	100	0.721
comGC/cglC	Streptococcus mitis SK321	66.667	95.192	0.635
comGC/cglC	Streptococcus mitis NCTC 12261	69.565	88.462	0.615
comGC/cglC	Streptococcus pneumoniae R6	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae Rx1	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae D39	63.636	95.192	0.606
comGC/cglC	Streptococcus pneumoniae TIGR4	63.636	95.192	0.606
comGC	Lactococcus lactis subsp. cremoris KW2	55.446	97.115	0.538
comGC	Streptococcus suis isolate S10	60.227	84.615	0.51