Detailed information NTG1017416

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DQL59_RS06855
• Genome accession: NZ_LS483326
• Coordinates: 1345412..1346152 (-)
• Length: 246 a.a.
• NCBI ID: WP_111681291.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12045
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1340412..1351152

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL59_RS06830 (NCTC12045_01352)	-	1341368..1342072 (-)	705	WP_111681290.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
DQL59_RS06835 (NCTC12045_01353)	rpmH	1342346..1342480 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
DQL59_RS06840 (NCTC12045_01354)	jag	1342794..1343708 (-)	915	WP_014407283.1	RNA-binding cell elongation regulator Jag/EloR	-
DQL59_RS06845 (NCTC12045_01355)	-	1343720..1344547 (-)	828	WP_002991181.1	YidC/Oxa1 family membrane protein insertase	-
DQL59_RS06850 (NCTC12045_01356)	rnpA	1344513..1344872 (-)	360	WP_002992035.1	ribonuclease P protein component	-
DQL59_RS06855 (NCTC12045_01357)	comE/blpR	1345412..1346152 (-)	741	WP_111681291.1	response regulator transcription factor	Regulator
DQL59_RS06860 (NCTC12045_01358)	-	1346156..1347439 (-)	1284	WP_010921869.1	sensor histidine kinase	-
DQL59_RS06865 (NCTC12045_01359)	-	1347436..1348782 (-)	1347	WP_111681292.1	sensor histidine kinase	-
DQL59_RS06870 (NCTC12045_01360)	gltX	1349177..1350622 (-)	1446	WP_111681293.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28911.50 Da
• Isoelectric Point: 6.4841

>NTDB_id=1017416 DQL59_RS06855 WP_111681291.1 1345412..1346152(-) (comE/blpR) [Streptococcus pyogenes strain NCTC12045]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYSNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=1017416 DQL59_RS06855 WP_111681291.1 1345412..1346152(-) (comE/blpR) [Streptococcus pyogenes strain NCTC12045]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGTATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTTT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATTCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATAGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.444	97.154	0.451
comE/comE1	Streptococcus equinus JB1	41.176	96.748	0.398
comE/comE2	Streptococcus equinus JB1	39.024	100	0.39
comE	Streptococcus pneumoniae Rx1	38.115	99.187	0.378
comE	Streptococcus pneumoniae D39	38.115	99.187	0.378
comE	Streptococcus pneumoniae R6	38.115	99.187	0.378
comE	Streptococcus pneumoniae TIGR4	38.115	99.187	0.378
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.5	100	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	37.5	100	0.378
comE	Streptococcus mitis NCTC 12261	37.344	97.967	0.366
comE	Streptococcus mitis SK321	37.344	97.967	0.366