Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ABN019_RS04505 Genome accession   NZ_CP158111
Coordinates   927244..928485 (+) Length   413 a.a.
NCBI ID   WP_005688669.1    Uniprot ID   A0A508YV25
Organism   Lacticaseibacillus rhamnosus strain BIM B-189     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 902491..954254 927244..928485 within 0


Gene organization within MGE regions


Location: 902491..954254
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABN019_RS04380 (ABN019_04385) - 902561..902827 (+) 267 WP_005687240.1 ACT domain-containing protein -
  ABN019_RS04385 (ABN019_04390) - 902982..904325 (+) 1344 WP_005688634.1 PFL family protein -
  ABN019_RS04390 (ABN019_04395) - 904492..905559 (+) 1068 WP_014571209.1 competence protein CoiA family protein -
  ABN019_RS04395 (ABN019_04400) - 905800..906435 (-) 636 WP_005687248.1 DsbA family protein -
  ABN019_RS04400 (ABN019_04405) - 906505..907098 (-) 594 WP_005688639.1 CYTH domain-containing protein -
  ABN019_RS04405 (ABN019_04410) - 907265..907942 (+) 678 WP_005713649.1 GTP pyrophosphokinase family protein -
  ABN019_RS04410 (ABN019_04415) - 907944..908741 (+) 798 WP_005687253.1 NAD kinase -
  ABN019_RS04415 (ABN019_04420) - 908741..909643 (+) 903 WP_005688644.1 RluA family pseudouridine synthase -
  ABN019_RS04420 (ABN019_04425) - 909787..910845 (-) 1059 WP_005688645.1 FAD:protein FMN transferase -
  ABN019_RS04425 (ABN019_04430) - 911062..911700 (-) 639 WP_005688646.1 copper homeostasis protein CutC -
  ABN019_RS04430 (ABN019_04435) - 911720..912538 (-) 819 WP_005688647.1 undecaprenyl-diphosphate phosphatase -
  ABN019_RS04435 (ABN019_04440) - 912743..913783 (-) 1041 WP_005688649.1 lactonase family protein -
  ABN019_RS04440 (ABN019_04445) - 914027..914401 (+) 375 WP_005688651.1 PTS glucitol/sorbitol transporter subunit IIA -
  ABN019_RS04445 (ABN019_04450) rpsN 914451..914720 (-) 270 WP_003564153.1 30S ribosomal protein S14 -
  ABN019_RS04450 (ABN019_04455) - 914835..915812 (-) 978 WP_014571210.1 GMP reductase -
  ABN019_RS04455 (ABN019_04460) - 916008..916955 (-) 948 WP_005688655.1 magnesium transporter CorA family protein -
  ABN019_RS04460 (ABN019_04465) - 917021..917863 (+) 843 WP_005688657.1 methyltransferase domain-containing protein -
  ABN019_RS04465 (ABN019_04470) trmL 918349..918858 (+) 510 WP_005688659.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
  ABN019_RS04470 (ABN019_04475) - 918882..919289 (+) 408 WP_005687267.1 DUF1149 family protein -
  ABN019_RS04475 (ABN019_04480) - 919815..922115 (+) 2301 WP_014571214.1 DNA translocase FtsK -
  ABN019_RS04480 (ABN019_04485) - 922124..923386 (+) 1263 WP_014571215.1 pitrilysin family protein -
  ABN019_RS04485 (ABN019_04490) - 923383..924675 (+) 1293 WP_005688664.1 pitrilysin family protein -
  ABN019_RS04490 (ABN019_04495) - 924675..925403 (+) 729 WP_005688666.1 SDR family oxidoreductase -
  ABN019_RS04495 (ABN019_04500) - 925490..926425 (+) 936 WP_005688668.1 helix-turn-helix domain-containing protein -
  ABN019_RS04500 (ABN019_04505) pgsA 926422..927015 (+) 594 WP_005688184.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  ABN019_RS04505 (ABN019_04510) cinA 927244..928485 (+) 1242 WP_005688669.1 competence/damage-inducible protein A Machinery gene
  ABN019_RS04510 (ABN019_04515) recA 928537..929589 (+) 1053 WP_005688671.1 recombinase RecA Machinery gene
  ABN019_RS04515 (ABN019_04520) rny 930214..931785 (+) 1572 WP_005684479.1 ribonuclease Y -
  ABN019_RS04520 (ABN019_04525) - 931874..932530 (-) 657 WP_024129572.1 YigZ family protein -
  ABN019_RS04525 (ABN019_04530) - 932558..933823 (+) 1266 WP_014571217.1 DEAD/DEAH box helicase -
  ABN019_RS04530 (ABN019_04535) - 933982..934500 (+) 519 WP_005688681.1 ComF family protein -
  ABN019_RS04535 (ABN019_04540) raiA 934625..935182 (+) 558 WP_005684485.1 ribosome-associated translation inhibitor RaiA -
  ABN019_RS04540 (ABN019_04545) secA 935766..938129 (+) 2364 WP_005688686.1 preprotein translocase subunit SecA -
  ABN019_RS04545 (ABN019_04550) prfB 938270..939386 (+) 1117 WP_154243967.1 peptide chain release factor 2 -
  ABN019_RS04550 (ABN019_04555) ftsE 939463..940149 (+) 687 WP_005684489.1 cell division ATP-binding protein FtsE -
  ABN019_RS04555 (ABN019_04560) ftsX 940139..941026 (+) 888 WP_005684490.1 permease-like cell division protein FtsX -
  ABN019_RS04560 (ABN019_04565) - 941297..942394 (+) 1098 WP_014571221.1 PDZ domain-containing protein -
  ABN019_RS04565 (ABN019_04570) - 942391..943095 (+) 705 WP_005688690.1 response regulator transcription factor -
  ABN019_RS04570 (ABN019_04575) - 943088..943957 (+) 870 Protein_870 PAS domain-containing protein -
  ABN019_RS04575 (ABN019_04580) - 944022..945038 (-) 1017 WP_019728331.1 IS30 family transposase -
  ABN019_RS04580 (ABN019_04585) - 945141..945947 (+) 807 Protein_872 ATP-binding protein -
  ABN019_RS04585 (ABN019_04590) - 946037..946903 (+) 867 WP_005688693.1 phosphate ABC transporter substrate-binding protein PstS family protein -
  ABN019_RS04590 (ABN019_04595) pstC 947051..947974 (+) 924 WP_005684497.1 phosphate ABC transporter permease subunit PstC -
  ABN019_RS04595 (ABN019_04600) pstA 947971..948855 (+) 885 WP_005684499.1 phosphate ABC transporter permease PstA -
  ABN019_RS04600 (ABN019_04605) pstB 948926..949744 (+) 819 WP_014571222.1 phosphate ABC transporter ATP-binding protein PstB -
  ABN019_RS04605 (ABN019_04610) pstB 949754..950518 (+) 765 WP_005684501.1 phosphate ABC transporter ATP-binding protein PstB -
  ABN019_RS04610 (ABN019_04615) phoU 950529..951206 (+) 678 WP_005684502.1 phosphate signaling complex protein PhoU -
  ABN019_RS04615 (ABN019_04620) liaX 951913..953403 (+) 1491 WP_005688699.1 daptomycin-sensing surface protein LiaX -
  ABN019_RS04620 (ABN019_04625) - 953415..953675 (+) 261 WP_005688700.1 hypothetical protein -
  ABN019_RS04625 (ABN019_04630) - 953678..954013 (+) 336 WP_005684507.1 phage holin family protein -

Sequence

Protein


Download         Length: 413 a.a.        Molecular weight: 44384.10 Da        Isoelectric Point: 8.3237

>NTDB_id=1009755 ABN019_RS04505 WP_005688669.1 927244..928485(+) (cinA) [Lacticaseibacillus rhamnosus strain BIM B-189]
MQAEIIAIGTEILMGQITNTNGAYMAKQLATLGIASYHQQVVGDNAKRLADAISLAEQRSDIVILIGGLGPTPDDLTKQT
LAAHLNLPLVEDAGAMAKLAARVKQQQRPMTPNNRLQAMYPKGAIVLANRVGLAVGAWVEQRQHAYVLLPGPPKEFVPMV
DHELLPRLAKYSGHQEVLESRVMRFFGVGESQLVTDLSDLIANQTNPTLATYIKDHEVTVRVTASGKTQAEAAAKLEPMI
GIIMDREGRYFYGYGDDNSLAQELVKALAASDKQISAAESLTAGAFQAALGDVPGVSAYFKGGFVTYALATKAAFLNIDA
RQLAEHGVVSEFTAKAMAEHARQRAAADIAVSFTGVAGPDKLEGQPAGTVWIGLARLGEKPIAQVYHFPGGRNDVRKRAV
MTGMMMVLKRLRE

Nucleotide


Download         Length: 1242 bp        

>NTDB_id=1009755 ABN019_RS04505 WP_005688669.1 927244..928485(+) (cinA) [Lacticaseibacillus rhamnosus strain BIM B-189]
ATGCAAGCAGAAATTATTGCTATCGGAACGGAAATTCTGATGGGACAAATCACAAATACAAATGGCGCGTATATGGCTAA
ACAACTGGCTACATTAGGTATTGCAAGCTATCATCAACAGGTTGTTGGGGATAACGCAAAACGACTGGCTGACGCGATAA
GTTTGGCTGAACAACGCAGTGATATCGTTATTTTGATTGGCGGTTTAGGACCAACACCGGATGATTTAACGAAGCAAACC
CTAGCCGCACACCTGAATTTACCCTTGGTGGAAGACGCTGGCGCTATGGCCAAGTTGGCTGCGCGGGTTAAACAACAGCA
ACGTCCAATGACACCCAATAATCGCTTGCAAGCGATGTATCCCAAAGGCGCAATCGTATTGGCCAATCGTGTTGGGTTGG
CGGTCGGCGCATGGGTTGAGCAGCGCCAACACGCCTATGTTTTATTGCCGGGACCACCTAAAGAGTTTGTGCCAATGGTT
GATCATGAACTGTTGCCACGACTGGCAAAATATAGCGGGCATCAAGAAGTTTTGGAAAGTCGCGTGATGCGTTTCTTTGG
TGTCGGCGAATCGCAACTTGTGACAGATTTAAGTGATTTAATTGCCAACCAGACGAATCCGACACTTGCAACTTATATAA
AAGATCATGAGGTGACAGTTCGGGTAACTGCGAGTGGCAAAACACAAGCAGAAGCCGCGGCAAAACTTGAGCCAATGATC
GGCATCATTATGGATCGTGAAGGCCGCTACTTTTACGGCTACGGTGACGATAACAGTCTTGCTCAGGAATTAGTCAAAGC
ATTGGCGGCTAGTGATAAGCAAATTAGTGCCGCTGAAAGCCTGACTGCAGGTGCATTTCAAGCGGCATTGGGAGACGTTC
CGGGAGTCTCGGCTTATTTCAAAGGCGGCTTCGTTACGTACGCTTTAGCGACAAAAGCTGCATTTTTAAATATCGATGCC
CGTCAGCTAGCAGAACATGGTGTGGTGAGTGAATTTACTGCCAAAGCAATGGCAGAGCATGCTCGTCAACGAGCCGCGGC
AGACATTGCCGTTAGTTTTACCGGAGTTGCCGGTCCTGACAAGCTGGAAGGACAGCCAGCCGGCACCGTCTGGATTGGTT
TGGCGCGGTTAGGAGAGAAACCAATAGCACAAGTTTATCATTTTCCGGGTGGGCGAAATGACGTCCGCAAGCGCGCCGTT
ATGACGGGGATGATGATGGTGTTGAAGCGTTTACGCGAATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(180-253)

Competence-damaged protein (CinA)

(258-410)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A508YV25

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

51.781

100

0.528
  cinA Streptococcus mitis NCTC 12261

51.781

100

0.528
  cinA Streptococcus pneumoniae TIGR4

51.306

100

0.523
  cinA Streptococcus pneumoniae Rx1

50.831

100

0.518
  cinA Streptococcus pneumoniae R6

50.831

100

0.518
  cinA Streptococcus pneumoniae D39

50.594

100

0.516
  cinA Streptococcus mutans UA159

51.202

100

0.516
  cinA Bacillus subtilis subsp. subtilis str. 168

44.417

99.758

0.443
  cinA Streptococcus suis isolate S10

41.534

91.525

0.38

Multiple sequence alignment