Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 840129..841084 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag AP033_RS03805 Protein ID WP_000118351.1
Coordinates 840129..840662 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag AP033_RS20035 Protein ID WP_001882332.1
Coordinates 840659..841084 (-) Length 142 a.a.

Genomic Context

AP033_RS03765AP033_RS03770AP033_RS03775AP033_RS03780AP033_RS03785AP033_RS03790AP033_RS03795AP033_RS03800AP033_RS03805AP033_RS20035AP033_RS03815AP033_RS03820AP033_RS19075AP033_RS19080AP033_RS19085AP033_RS03825AP033_RS03830AP033_RS03835AP033_RS03840
Location: 836032..836250 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 836314..836751 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 836870..837079 (210 bp)
Type: Others
Protein ID: Protein_732
Location: 837215..837604 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 837779..838021 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 838229..839146 (918 bp)
Type: Others
Protein ID: WP_033935911.1
Location: 839380..839682 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 839670..839927 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 840129..840662 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 840659..841084 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 841151..841522 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 841770..842030 (261 bp)
Type: Others
Protein ID: WP_032468027.1
Location: 842048..842208 (161 bp)
Type: Others
Protein ID: Protein_742
Location: 842442..842666 (225 bp)
Type: Others
Protein ID: WP_161571222.1
Location: 842996..843106 (111 bp)
Type: Others
Protein ID: WP_076025930.1
Location: 843491..843793 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 843781..844038 (258 bp)
Type: Others
Protein ID: WP_070961997.1
Location: 844511..845491 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 845561..845887 (327 bp)
Type: Others
Protein ID: Protein_748
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AP033_RS03765836032..836250-219WP_071908318.1GNAT family N-acetyltransferase-
AP033_RS03770836314..836751-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
AP033_RS03775836870..837079-210Protein_732GNAT family N-acetyltransferase-
AP033_RS03780837215..837604-390WP_001081302.1hypothetical protein-
AP033_RS03785837779..838021-243WP_000107462.1hypothetical protein-
AP033_RS03790838229..839146-918WP_033935911.1alpha/beta hydrolase-
AP033_RS03795839380..839682-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
AP033_RS03800839670..839927-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AP033_RS03805840129..840662-534WP_000118351.1GNAT family N-acetyltransferaseToxin
AP033_RS20035840659..841084-426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
AP033_RS03815841151..841522-372WP_001164080.1nucleotide pyrophosphohydrolase-
AP033_RS03820841770..842030-261WP_032468027.1DUF3709 domain-containing protein-
AP033_RS19075842048..842208-161Protein_742DUF3709 domain-containing protein-
AP033_RS19080842442..842666-225WP_161571222.1DUF3709 domain-containing protein-
AP033_RS19085842996..843106-111WP_076025930.1DUF645 family protein-
AP033_RS03825843491..843793-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
AP033_RS03830843781..844038-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AP033_RS03835844511..845491-981WP_000019368.1IS5-like element ISVch5 family transposase-
AP033_RS03840845561..845887-327Protein_748hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--836314..836751437
flankIS/Tn--844511..845491980
-insideIntegron--829699..942463112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T57704 WP_000118351.1 NZ_CP013013:c840662-840129 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T57704 NZ_CP013013:c840662-840129 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT57704 WP_001882332.1 NZ_CP013013:c841084-840659 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT57704 NZ_CP013013:c841084-840659 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References