57703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 839380..839927 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag AP033_RS03795 Protein ID WP_000229317.1
Coordinates 839380..839682 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag AP033_RS03800 Protein ID WP_000861987.1
Coordinates 839670..839927 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AP033_RS03760 834985..835857 - 873 WP_000254717.1 DUF3800 domain-containing protein -
AP033_RS03765 836032..836250 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
AP033_RS03770 836314..836751 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
AP033_RS03775 836870..837079 - 210 Protein_732 GNAT family N-acetyltransferase -
AP033_RS03780 837215..837604 - 390 WP_001081302.1 hypothetical protein -
AP033_RS03785 837779..838021 - 243 WP_000107462.1 hypothetical protein -
AP033_RS03790 838229..839146 - 918 WP_033935911.1 alpha/beta hydrolase -
AP033_RS03795 839380..839682 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AP033_RS03800 839670..839927 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AP033_RS03805 840129..840662 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
AP033_RS20035 840659..841084 - 426 WP_001882332.1 DUF1778 domain-containing protein -
AP033_RS03815 841151..841522 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
AP033_RS03820 841770..842030 - 261 WP_032468027.1 DUF3709 domain-containing protein -
AP033_RS19075 842048..842208 - 161 Protein_742 DUF3709 domain-containing protein -
AP033_RS19080 842442..842666 - 225 WP_161571222.1 DUF3709 domain-containing protein -
AP033_RS19085 842996..843106 - 111 WP_076025930.1 DUF645 family protein -
AP033_RS03825 843491..843793 - 303 WP_000229325.1 type II toxin-antitoxin system RelE/ParE family toxin -
AP033_RS03830 843781..844038 - 258 WP_070961997.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 836314..836751 437
flank IS/Tn - - 844511..845491 980
- inside Integron - - 829699..942463 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T57703 WP_000229317.1 NZ_CP013013:c839682-839380 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T57703 NZ_CP013013:c839682-839380 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT57703 WP_000861987.1 NZ_CP013013:c839927-839670 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT57703 NZ_CP013013:c839927-839670 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References