Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 839380..839927 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag AP033_RS03795 Protein ID WP_000229317.1
Coordinates 839380..839682 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag AP033_RS03800 Protein ID WP_000861987.1
Coordinates 839670..839927 (-) Length 86 a.a.

Genomic Context

AP033_RS03760AP033_RS03765AP033_RS03770AP033_RS03775AP033_RS03780AP033_RS03785AP033_RS03790AP033_RS03795AP033_RS03800AP033_RS03805AP033_RS20035AP033_RS03815AP033_RS03820AP033_RS19075AP033_RS19080AP033_RS19085AP033_RS03825AP033_RS03830
Location: 834985..835857 (873 bp)
Type: Others
Protein ID: WP_000254717.1
Location: 836032..836250 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 836314..836751 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 836870..837079 (210 bp)
Type: Others
Protein ID: Protein_732
Location: 837215..837604 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 837779..838021 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 838229..839146 (918 bp)
Type: Others
Protein ID: WP_033935911.1
Location: 839380..839682 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 839670..839927 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 840129..840662 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 840659..841084 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 841151..841522 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 841770..842030 (261 bp)
Type: Others
Protein ID: WP_032468027.1
Location: 842048..842208 (161 bp)
Type: Others
Protein ID: Protein_742
Location: 842442..842666 (225 bp)
Type: Others
Protein ID: WP_161571222.1
Location: 842996..843106 (111 bp)
Type: Others
Protein ID: WP_076025930.1
Location: 843491..843793 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 843781..844038 (258 bp)
Type: Others
Protein ID: WP_070961997.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AP033_RS03760834985..835857-873WP_000254717.1DUF3800 domain-containing protein-
AP033_RS03765836032..836250-219WP_071908318.1GNAT family N-acetyltransferase-
AP033_RS03770836314..836751-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
AP033_RS03775836870..837079-210Protein_732GNAT family N-acetyltransferase-
AP033_RS03780837215..837604-390WP_001081302.1hypothetical protein-
AP033_RS03785837779..838021-243WP_000107462.1hypothetical protein-
AP033_RS03790838229..839146-918WP_033935911.1alpha/beta hydrolase-
AP033_RS03795839380..839682-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AP033_RS03800839670..839927-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
AP033_RS03805840129..840662-534WP_000118351.1GNAT family N-acetyltransferase-
AP033_RS20035840659..841084-426WP_001882332.1DUF1778 domain-containing protein-
AP033_RS03815841151..841522-372WP_001164080.1nucleotide pyrophosphohydrolase-
AP033_RS03820841770..842030-261WP_032468027.1DUF3709 domain-containing protein-
AP033_RS19075842048..842208-161Protein_742DUF3709 domain-containing protein-
AP033_RS19080842442..842666-225WP_161571222.1DUF3709 domain-containing protein-
AP033_RS19085842996..843106-111WP_076025930.1DUF645 family protein-
AP033_RS03825843491..843793-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
AP033_RS03830843781..844038-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--836314..836751437
flankIS/Tn--844511..845491980
-insideIntegron--829699..942463112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T57703 WP_000229317.1 NZ_CP013013:c839682-839380 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T57703 NZ_CP013013:c839682-839380 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT57703 WP_000861987.1 NZ_CP013013:c839927-839670 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT57703 NZ_CP013013:c839927-839670 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References