Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 838182..838729 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag NH62_RS03785 Protein ID WP_000229317.1
Coordinates 838182..838484 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag NH62_RS03790 Protein ID WP_000861987.1
Coordinates 838472..838729 (-) Length 86 a.a.

Genomic Context

NH62_RS03750NH62_RS03755NH62_RS03760NH62_RS03765NH62_RS03770NH62_RS03775NH62_RS03780NH62_RS03785NH62_RS03790NH62_RS03795NH62_RS03800NH62_RS03805NH62_RS03810NH62_RS19125NH62_RS19130NH62_RS19135NH62_RS03815NH62_RS03820
Location: 833787..834659 (873 bp)
Type: Others
Protein ID: WP_000254717.1
Location: 834834..835052 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 835116..835553 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 835672..835881 (210 bp)
Type: Others
Protein ID: Protein_730
Location: 836017..836406 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 836581..836823 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 837031..837948 (918 bp)
Type: Others
Protein ID: WP_033935911.1
Location: 838182..838484 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 838472..838729 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 838931..839464 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 839461..839886 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 839953..840324 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 840572..840832 (261 bp)
Type: Others
Protein ID: WP_032468027.1
Location: 840850..841010 (161 bp)
Type: Others
Protein ID: Protein_740
Location: 841244..841468 (225 bp)
Type: Others
Protein ID: WP_161571222.1
Location: 841798..841908 (111 bp)
Type: Others
Protein ID: WP_076025930.1
Location: 842293..842595 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 842583..842840 (258 bp)
Type: Others
Protein ID: WP_070961997.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NH62_RS03750833787..834659-873WP_000254717.1DUF3800 domain-containing protein-
NH62_RS03755834834..835052-219WP_071908318.1GNAT family N-acetyltransferase-
NH62_RS03760835116..835553-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
NH62_RS03765835672..835881-210Protein_730GNAT family N-acetyltransferase-
NH62_RS03770836017..836406-390WP_001081302.1hypothetical protein-
NH62_RS03775836581..836823-243WP_000107462.1hypothetical protein-
NH62_RS03780837031..837948-918WP_033935911.1alpha/beta hydrolase-
NH62_RS03785838182..838484-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NH62_RS03790838472..838729-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
NH62_RS03795838931..839464-534WP_000118351.1GNAT family N-acetyltransferase-
NH62_RS03800839461..839886-426WP_001882332.1DUF1778 domain-containing protein-
NH62_RS03805839953..840324-372WP_001164080.1nucleotide pyrophosphohydrolase-
NH62_RS03810840572..840832-261WP_032468027.1DUF3709 domain-containing protein-
NH62_RS19125840850..841010-161Protein_740DUF3709 domain-containing protein-
NH62_RS19130841244..841468-225WP_161571222.1DUF3709 domain-containing protein-
NH62_RS19135841798..841908-111WP_076025930.1DUF645 family protein-
NH62_RS03815842293..842595-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
NH62_RS03820842583..842840-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827256..947647120391
flankIS/Tn--835116..835553437
flankIS/Tn--843313..844293980
-insideIntegron--828501..941266112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T57656 WP_000229317.1 NZ_CP012997:c838484-838182 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T57656 NZ_CP012997:c838484-838182 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT57656 WP_000861987.1 NZ_CP012997:c838729-838472 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT57656 NZ_CP012997:c838729-838472 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References