57656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 838182..838729 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag NH62_RS03785 Protein ID WP_000229317.1
Coordinates 838182..838484 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag NH62_RS03790 Protein ID WP_000861987.1
Coordinates 838472..838729 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH62_RS03750 833787..834659 - 873 WP_000254717.1 DUF3800 domain-containing protein -
NH62_RS03755 834834..835052 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
NH62_RS03760 835116..835553 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
NH62_RS03765 835672..835881 - 210 Protein_730 GNAT family N-acetyltransferase -
NH62_RS03770 836017..836406 - 390 WP_001081302.1 hypothetical protein -
NH62_RS03775 836581..836823 - 243 WP_000107462.1 hypothetical protein -
NH62_RS03780 837031..837948 - 918 WP_033935911.1 alpha/beta hydrolase -
NH62_RS03785 838182..838484 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NH62_RS03790 838472..838729 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NH62_RS03795 838931..839464 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
NH62_RS03800 839461..839886 - 426 WP_001882332.1 DUF1778 domain-containing protein -
NH62_RS03805 839953..840324 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
NH62_RS03810 840572..840832 - 261 WP_032468027.1 DUF3709 domain-containing protein -
NH62_RS19125 840850..841010 - 161 Protein_740 DUF3709 domain-containing protein -
NH62_RS19130 841244..841468 - 225 WP_161571222.1 DUF3709 domain-containing protein -
NH62_RS19135 841798..841908 - 111 WP_076025930.1 DUF645 family protein -
NH62_RS03815 842293..842595 - 303 WP_000229325.1 type II toxin-antitoxin system RelE/ParE family toxin -
NH62_RS03820 842583..842840 - 258 WP_070961997.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827256..947647 120391
flank IS/Tn - - 835116..835553 437
flank IS/Tn - - 843313..844293 980
- inside Integron - - 828501..941266 112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T57656 WP_000229317.1 NZ_CP012997:c838484-838182 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T57656 NZ_CP012997:c838484-838182 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT57656 WP_000861987.1 NZ_CP012997:c838729-838472 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT57656 NZ_CP012997:c838729-838472 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References