Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 397481..398247 Replicon chromosome II
Accession NC_012580
Organism Vibrio cholerae M66-2

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCM66_RS15350 Protein ID WP_000982260.1
Coordinates 397481..397978 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VCM66_RS15355 Protein ID WP_000246253.1
Coordinates 397975..398247 (-) Length 91 a.a.

Genomic Context

VCM66_RS15315VCM66_RS15320VCM66_RS15325VCM66_RS19425VCM66_RS15330VCM66_RS15335VCM66_RS15340VCM66_RS15345VCM66_RS19005VCM66_RS15360VCM66_RS15365VCM66_RS15370VCM66_RS19595VCM66_RS15380VCM66_RS15385VCM66_RS15390VCM66_RS15395VCM66_RS15400VCM66_RS15405VCM66_RS15350VCM66_RS15355
Location: 393343..393615 (273 bp)
Type: Others
Protein ID: Protein_401
Location: 393786..394478 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 394478..394879 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 394849..394992 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 395067..395480 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 395694..395945 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 395935..396222 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 396350..396805 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 397127..397279 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 398478..399146 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 399298..399585 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 399726..400097 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 400164..400589 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 400586..401119 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 401321..401578 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 401566..401868 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 402022..402231 (210 bp)
Type: Others
Protein ID: Protein_419
Location: 402350..402787 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 402851..403069 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 397481..397978 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 397975..398247 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCM66_RS15315393343..393615+273Protein_401CatB-related O-acetyltransferase-
VCM66_RS15320393786..394478+693WP_001047169.1GNAT family N-acetyltransferase-
VCM66_RS15325394478..394879+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
VCM66_RS19425394849..394992+144WP_071908341.1DUF3265 domain-containing protein-
VCM66_RS15330395067..395480+414WP_000049417.1VOC family protein-
VCM66_RS15335395694..395945+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCM66_RS15340395935..396222+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
VCM66_RS15345396350..396805+456WP_001245327.1GNAT family N-acetyltransferase-
VCM66_RS19005397127..397279+153WP_001884520.1DUF645 family protein-
VCM66_RS15350397481..397978-498WP_000982260.1GNAT family N-acetyltransferaseToxin
VCM66_RS15355397975..398247-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
VCM66_RS15360398478..399146+669WP_000043871.1hypothetical protein-
VCM66_RS15365399298..399585+288WP_000426470.1hypothetical protein-
VCM66_RS15370399726..400097+372WP_001164080.1nucleotide pyrophosphohydrolase-
VCM66_RS19595400164..400589+426WP_001882332.1DUF1778 domain-containing protein-
VCM66_RS15380400586..401119+534WP_000118351.1GNAT family N-acetyltransferase-
VCM66_RS15385401321..401578+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCM66_RS15390401566..401868+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
VCM66_RS15395402022..402231+210Protein_419GNAT family N-acetyltransferase-
VCM66_RS15400402350..402787+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
VCM66_RS15405402851..403069+219WP_071908318.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--305869..409778103909
-insideIntegron--310949..40940298453
flankIS/Tn--392295..393275980
flankIS/Tn--402350..402787437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T23716 WP_000982260.1 NC_012580:c397978-397481 [Vibrio cholerae M66-2]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T23716 NC_012580:c397978-397481 [Vibrio cholerae M66-2]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT23716 WP_000246253.1 NC_012580:c398247-397975 [Vibrio cholerae M66-2]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT23716 NC_012580:c398247-397975 [Vibrio cholerae M66-2]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References