Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4415059..4415648 Replicon chromosome
Accession AE015451
Organism Pseudomonas putida KT2440

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PP_3900 Protein ID AAN69494.1
Coordinates 4415400..4415648 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PP_3899 Protein ID AAN69493.1
Coordinates 4415059..4415391 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PP_3894 4410310..4411140 - 831 AAN69488.1 putative Phage replication protein O -
PP_3895 4411465..4411677 - 213 AAN69489.1 putative Regulatory protein Cro -
PP_3896 4411765..4412412 + 648 AAN69490.1 Transcriptional regulator, Cro/CI family -
PP_3897 4412470..4412883 + 414 AAN69491.1 conserved protein of unknown function -
PP_3898 4412927..4413163 + 237 AAN69492.1 conserved protein of unknown function -
PP_5643 4413330..4414322 + 993 AMM02978.1 conserved protein of unknown function -
PP_5644 4414325..4414891 + 567 AMM02979.1 conserved membrane protein of unknown function -
PP_3899 4415059..4415391 - 333 AAN69493.1 conserved protein of unknown function, hicB family Antitoxin
PP_3900 4415400..4415648 - 249 AAN69494.1 hypothetical protein Toxin
PP_3901 4415798..4416058 + 261 AAN69495.1 conserved protein of unknown function -
PP_3902 4416177..4416485 - 309 AAN69496.1 conserved protein of unknown function -
PP_3903 4416475..4416639 + 165 AAN69497.1 conserved protein of unknown function -
PP_3904 4416845..4417099 - 255 AAN69498.1 conserved protein of unknown function -
PP_3905 4417108..4417659 + 552 AAN69499.1 Transcriptional regulator, LuxR family -
PP_3906 4417679..4417948 + 270 AAN69500.1 conserved protein of unknown function -
PP_3907 4417945..4418403 + 459 AAN69501.1 conserved protein of unknown function -
PP_3908 4418485..4418835 + 351 AAN69502.1 conserved protein of unknown function -
PP_3909 4418849..4419127 - 279 AAN69503.1 conserved protein of unknown function -
PP_3910 4419234..4419785 + 552 AAN69504.2 conserved protein of unknown function -
PP_3911 4419800..4420183 + 384 AAN69505.1 conserved protein of unknown function -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4377646..4431298 53652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9137.67 Da        Isoelectric Point: 10.4156

>T20007 AAN69494.1 AE015451:c4415648-4415400 [Pseudomonas putida KT2440]
MSKQEKLLAKLLNKQAGFTWPELVTLLGGLGYRHIEGDGSRVKFDNGHPQAMINLHKPHPGNELKAYVKRQVIEHLKAGG
LI

Download         Length: 249 bp

>T20007 AE015451:c4415648-4415400 [Pseudomonas putida KT2440]
ATGTCTAAGCAAGAAAAGCTGCTCGCGAAGCTGCTGAACAAGCAAGCAGGATTCACTTGGCCTGAGCTGGTCACGCTGCT
GGGTGGGCTTGGATACCGCCATATCGAGGGTGATGGCAGCCGAGTGAAGTTCGACAATGGCCACCCGCAGGCAATGATCA
ACTTGCACAAGCCGCACCCCGGCAATGAGCTGAAGGCCTACGTTAAACGCCAGGTAATAGAGCACCTGAAAGCAGGAGGA
TTGATCTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12083.53 Da        Isoelectric Point: 5.0719

>AT20007 AAN69493.1 AE015451:c4415391-4415059 [Pseudomonas putida KT2440]
MLQYRGYYGSIEASPEDNCLFGKLQFIRALVSYEGETVAELTQAFRDAVDDYLDTCASLGQNPEIPCKGSFNVRVGHDLH
LAASVAATKQSISLNDLTRKALSEYLGHHA

Download         Length: 333 bp

>AT20007 AE015451:c4415391-4415059 [Pseudomonas putida KT2440]
ATGTTGCAGTACCGAGGCTACTACGGCTCCATTGAGGCCAGCCCCGAGGACAATTGCCTATTCGGCAAGCTTCAGTTCAT
CCGCGCCCTTGTCAGCTATGAGGGCGAGACGGTTGCTGAACTGACCCAGGCGTTCCGCGATGCAGTGGACGACTATCTCG
ACACCTGCGCATCACTCGGGCAGAACCCGGAAATTCCGTGCAAGGGGTCGTTCAATGTGAGGGTAGGGCACGACCTGCAC
CTAGCGGCCAGCGTGGCAGCCACCAAGCAAAGTATTTCCTTGAATGATCTGACACGCAAAGCGCTTAGTGAGTACCTGGG
TCATCACGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References