Detailed information of TA system TA135196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 838924..839879
• Replicon: chromosome
• Accession: NZ_CP042300
• Organism: Vibrio cholerae O1 strain AAS91

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: FKV26_RS17140
• Protein ID: WP_000118351.1
• Coordinates: 838924..839457 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FKV26_RS17145
• Protein ID: WP_001882332.1
• Coordinates: 839454..839879 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKV26_RS17095	834827..835045	-	219	WP_071908318.1	GNAT family N-acetyltransferase	-
FKV26_RS17100	835109..835546	-	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
FKV26_RS17105	835665..835874	-	210	Protein_729	GNAT family N-acetyltransferase	-
FKV26_RS17110	836010..836399	-	390	WP_001081302.1	hypothetical protein	-
FKV26_RS17115	836574..836816	-	243	WP_000107462.1	hypothetical protein	-
FKV26_RS17120	837024..837941	-	918	WP_033935911.1	alpha/beta hydrolase	-
FKV26_RS17125	838175..838477	-	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FKV26_RS17130	838465..838722	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FKV26_RS17140	838924..839457	-	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
FKV26_RS17145	839454..839879	-	426	WP_001882332.1	DUF1778 domain-containing protein	Antitoxin
FKV26_RS17150	839946..840317	-	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
FKV26_RS17155	840565..840825	-	261	WP_032468027.1	DUF3709 domain-containing protein	-
FKV26_RS17160	840843..841003	-	161	Protein_739	DUF3709 domain-containing protein	-
FKV26_RS17165	841237..841461	-	225	WP_161571222.1	DUF3709 domain-containing protein	-
FKV26_RS17170	841791..841901	-	111	WP_076025930.1	DUF645 family protein	-
FKV26_RS17175	842286..842588	-	303	WP_000229325.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FKV26_RS17180	842576..842833	-	258	WP_070961997.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FKV26_RS17190	843306..844286	-	981	WP_000019368.1	IS5-like element ISVch5 family transposase	-
FKV26_RS17195	844356..844682	-	327	Protein_745	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	827249..947639	120390
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	835109..835546	437
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0.001	flank	IS/Tn	-	-	843306..844286	980
	-	inside	Integron	-	-	828494..941258	112764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (57-133)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T135196 WP_000118351.1 NZ_CP042300:c839457-838924 [Vibrio cholerae O1]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T135196 NZ_CP042300:c839457-838924 [Vibrio cholerae O1]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15714.41 Da
• Isoelectric Point: 7.6659

>AT135196 WP_001882332.1 NZ_CP042300:c839879-839454 [Vibrio cholerae O1]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 426 bp

>AT135196 NZ_CP042300:c839879-839454 [Vibrio cholerae O1]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Structures

Toxin

• AlphaFold DB: Q9KM94