Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 838924..839879 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag FKV26_RS17140 Protein ID WP_000118351.1
Coordinates 838924..839457 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FKV26_RS17145 Protein ID WP_001882332.1
Coordinates 839454..839879 (-) Length 142 a.a.

Genomic Context

FKV26_RS17095FKV26_RS17100FKV26_RS17105FKV26_RS17110FKV26_RS17115FKV26_RS17120FKV26_RS17125FKV26_RS17130FKV26_RS17140FKV26_RS17145FKV26_RS17150FKV26_RS17155FKV26_RS17160FKV26_RS17165FKV26_RS17170FKV26_RS17175FKV26_RS17180FKV26_RS17190FKV26_RS17195
Location: 834827..835045 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 835109..835546 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 835665..835874 (210 bp)
Type: Others
Protein ID: Protein_729
Location: 836010..836399 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 836574..836816 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 837024..837941 (918 bp)
Type: Others
Protein ID: WP_033935911.1
Location: 838175..838477 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 838465..838722 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 838924..839457 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 839454..839879 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 839946..840317 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 840565..840825 (261 bp)
Type: Others
Protein ID: WP_032468027.1
Location: 840843..841003 (161 bp)
Type: Others
Protein ID: Protein_739
Location: 841237..841461 (225 bp)
Type: Others
Protein ID: WP_161571222.1
Location: 841791..841901 (111 bp)
Type: Others
Protein ID: WP_076025930.1
Location: 842286..842588 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 842576..842833 (258 bp)
Type: Others
Protein ID: WP_070961997.1
Location: 843306..844286 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 844356..844682 (327 bp)
Type: Others
Protein ID: Protein_745
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FKV26_RS17095834827..835045-219WP_071908318.1GNAT family N-acetyltransferase-
FKV26_RS17100835109..835546-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
FKV26_RS17105835665..835874-210Protein_729GNAT family N-acetyltransferase-
FKV26_RS17110836010..836399-390WP_001081302.1hypothetical protein-
FKV26_RS17115836574..836816-243WP_000107462.1hypothetical protein-
FKV26_RS17120837024..837941-918WP_033935911.1alpha/beta hydrolase-
FKV26_RS17125838175..838477-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
FKV26_RS17130838465..838722-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FKV26_RS17140838924..839457-534WP_000118351.1GNAT family N-acetyltransferaseToxin
FKV26_RS17145839454..839879-426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
FKV26_RS17150839946..840317-372WP_001164080.1nucleotide pyrophosphohydrolase-
FKV26_RS17155840565..840825-261WP_032468027.1DUF3709 domain-containing protein-
FKV26_RS17160840843..841003-161Protein_739DUF3709 domain-containing protein-
FKV26_RS17165841237..841461-225WP_161571222.1DUF3709 domain-containing protein-
FKV26_RS17170841791..841901-111WP_076025930.1DUF645 family protein-
FKV26_RS17175842286..842588-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
FKV26_RS17180842576..842833-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FKV26_RS17190843306..844286-981WP_000019368.1IS5-like element ISVch5 family transposase-
FKV26_RS17195844356..844682-327Protein_745hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827249..947639120390
flankIS/Tn--835109..835546437
flankIS/Tn--843306..844286980
-insideIntegron--828494..941258112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T135196 WP_000118351.1 NZ_CP042300:c839457-838924 [Vibrio cholerae O1]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T135196 NZ_CP042300:c839457-838924 [Vibrio cholerae O1]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT135196 WP_001882332.1 NZ_CP042300:c839879-839454 [Vibrio cholerae O1]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT135196 NZ_CP042300:c839879-839454 [Vibrio cholerae O1]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References