135195

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 838175..838722 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag FKV26_RS17125 Protein ID WP_000229317.1
Coordinates 838175..838477 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag FKV26_RS17130 Protein ID WP_000861987.1
Coordinates 838465..838722 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKV26_RS17090 833780..834652 - 873 WP_000254717.1 DUF3800 domain-containing protein -
FKV26_RS17095 834827..835045 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
FKV26_RS17100 835109..835546 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
FKV26_RS17105 835665..835874 - 210 Protein_729 GNAT family N-acetyltransferase -
FKV26_RS17110 836010..836399 - 390 WP_001081302.1 hypothetical protein -
FKV26_RS17115 836574..836816 - 243 WP_000107462.1 hypothetical protein -
FKV26_RS17120 837024..837941 - 918 WP_033935911.1 alpha/beta hydrolase -
FKV26_RS17125 838175..838477 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FKV26_RS17130 838465..838722 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FKV26_RS17140 838924..839457 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
FKV26_RS17145 839454..839879 - 426 WP_001882332.1 DUF1778 domain-containing protein -
FKV26_RS17150 839946..840317 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
FKV26_RS17155 840565..840825 - 261 WP_032468027.1 DUF3709 domain-containing protein -
FKV26_RS17160 840843..841003 - 161 Protein_739 DUF3709 domain-containing protein -
FKV26_RS17165 841237..841461 - 225 WP_161571222.1 DUF3709 domain-containing protein -
FKV26_RS17170 841791..841901 - 111 WP_076025930.1 DUF645 family protein -
FKV26_RS17175 842286..842588 - 303 WP_000229325.1 type II toxin-antitoxin system RelE/ParE family toxin -
FKV26_RS17180 842576..842833 - 258 WP_070961997.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827249..947639 120390
flank IS/Tn - - 835109..835546 437
flank IS/Tn - - 843306..844286 980
- inside Integron - - 828494..941258 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T135195 WP_000229317.1 NZ_CP042300:c838477-838175 [Vibrio cholerae O1]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T135195 NZ_CP042300:c838477-838175 [Vibrio cholerae O1]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT135195 WP_000861987.1 NZ_CP042300:c838722-838465 [Vibrio cholerae O1]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT135195 NZ_CP042300:c838722-838465 [Vibrio cholerae O1]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References