Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ABC812_RS09175 Genome accession   NZ_CP155537
Coordinates   1780809..1782065 (-) Length   418 a.a.
NCBI ID   WP_000642700.1    Uniprot ID   A0A2U3RWX3
Organism   Streptococcus pneumoniae strain DP1322     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1773479..1795900 1780809..1782065 within 0


Gene organization within MGE regions


Location: 1773479..1795900
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC812_RS09130 (ABC812_09125) - 1773479..1773676 (-) 198 WP_000890144.1 hypothetical protein -
  ABC812_RS09135 (ABC812_09130) - 1773680..1774474 (-) 795 WP_001101210.1 hypothetical protein -
  ABC812_RS09140 (ABC812_09135) - 1774882..1775307 (-) 426 WP_000204065.1 hypothetical protein -
  ABC812_RS09145 (ABC812_09140) - 1775436..1775795 (-) 360 WP_000749822.1 hypothetical protein -
  ABC812_RS09150 (ABC812_09145) - 1775841..1776047 (-) 207 WP_000366091.1 hypothetical protein -
  ABC812_RS09155 (ABC812_09150) - 1776034..1776207 (-) 174 WP_000289349.1 helix-turn-helix transcriptional regulator -
  ABC812_RS09160 (ABC812_09155) lytA 1776579..1777535 (-) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  ABC812_RS09165 (ABC812_09160) - 1777911..1779281 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  ABC812_RS09170 (ABC812_09165) recA 1779588..1780754 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  ABC812_RS09175 (ABC812_09170) cinA 1780809..1782065 (-) 1257 WP_000642700.1 competence/damage-inducible protein A Machinery gene
  ABC812_RS09180 (ABC812_09175) - 1782150..1783166 (-) 1017 WP_000239282.1 LCP family protein -
  ABC812_RS09185 (ABC812_09180) - 1783174..1783692 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  ABC812_RS09190 (ABC812_09185) tsaE 1783682..1784125 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  ABC812_RS09195 (ABC812_09190) - 1784211..1784832 (-) 622 Protein_1799 hypothetical protein -
  ABC812_RS09200 (ABC812_09195) - 1785215..1786078 (-) 864 WP_001093641.1 helix-turn-helix transcriptional regulator -
  ABC812_RS09205 (ABC812_09200) - 1786270..1786440 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  ABC812_RS09210 (ABC812_09205) pneA1 1786543..1786767 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  ABC812_RS09215 (ABC812_09210) pneA2 1786774..1786962 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  ABC812_RS09220 (ABC812_09215) lanM 1787078..1790068 (+) 2991 WP_000875575.1 type 2 lanthipeptide synthetase LanM -
  ABC812_RS09225 (ABC812_09220) - 1790418..1791122 (+) 705 WP_001033170.1 flavodoxin family protein -
  ABC812_RS09230 (ABC812_09225) - 1791103..1792032 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  ABC812_RS09235 (ABC812_09230) - 1792029..1794137 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  ABC812_RS09240 (ABC812_09235) - 1794161..1795900 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45036.36 Da        Isoelectric Point: 4.5211

>NTDB_id=997503 ABC812_RS09175 WP_000642700.1 1780809..1782065(-) (cinA) [Streptococcus pneumoniae strain DP1322]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGATEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=997503 ABC812_RS09175 WP_000642700.1 1780809..1782065(-) (cinA) [Streptococcus pneumoniae strain DP1322]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGGCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2U3RWX3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

100

100

1
  cinA Streptococcus pneumoniae R6

100

100

1
  cinA Streptococcus pneumoniae D39

99.761

100

0.998
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.301

100

0.933
  cinA Streptococcus mitis NCTC 12261

93.062

100

0.931
  cinA Streptococcus mutans UA159

70.574

100

0.706
  cinA Streptococcus suis isolate S10

54.808

99.522

0.545
  cinA Bacillus subtilis subsp. subtilis str. 168

45.215

100

0.452

Multiple sequence alignment