Detailed information NTG0997445

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ABC804_RS08455
• Genome accession: NZ_CP155536
• Coordinates: 1602255..1602842 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain M264-3
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1597255..1607842

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC804_RS08420 (ABC804_08415)	-	1598096..1598707 (-)	612	WP_000394047.1	type II CAAX endopeptidase family protein	-
ABC804_RS08425 (ABC804_08420)	blpZ	1598737..1598985 (-)	249	WP_000276499.1	immunity protein BlpZ	-
ABC804_RS08430 (ABC804_08425)	-	1599027..1599716 (-)	690	WP_000760526.1	CPBP family intramembrane glutamic endopeptidase	-
ABC804_RS08435 (ABC804_08430)	-	1599768..1600151 (-)	384	WP_000877381.1	hypothetical protein	-
ABC804_RS08440 (ABC804_08435)	-	1600937..1601056 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
ABC804_RS08445 (ABC804_08440)	cipB	1601160..1601309 (-)	150	WP_001808912.1	bacteriocin-like peptide BlpO	Regulator
ABC804_RS08450 (ABC804_08445)	blpI	1601776..1601973 (-)	198	WP_001093258.1	bacteriocin-like peptide BlpI	-
ABC804_RS08455 (ABC804_08450)	comA/nlmT	1602255..1602842 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
ABC804_RS08460 (ABC804_08455)	comA/nlmT	1602787..1603512 (+)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator
ABC804_RS08465 (ABC804_08460)	comA/nlmT	1603502..1603942 (+)	441	WP_001808911.1	ATP-binding cassette domain-containing protein	Regulator
ABC804_RS08470 (ABC804_08465)	comA/nlmT	1603926..1604414 (+)	489	WP_307774349.1	ATP-binding cassette domain-containing protein	Regulator
ABC804_RS08475 (ABC804_08470)	-	1604425..1605786 (+)	1362	WP_001069092.1	bacteriocin secretion accessory protein	-
ABC804_RS08480 (ABC804_08475)	blpC	1605843..1605998 (+)	156	WP_000358813.1	quorum-sensing system pheromone BlpC	-
ABC804_RS08485 (ABC804_08480)	-	1606040..1607380 (-)	1341	WP_001017622.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=997445 ABC804_RS08455 WP_000205166.1 1602255..1602842(+) (comA/nlmT) [Streptococcus pneumoniae strain M264-3]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=997445 ABC804_RS08455 WP_000205166.1 1602255..1602842(+) (comA/nlmT) [Streptococcus pneumoniae strain M264-3]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497