Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   AAYT22_RS08690 Genome accession   NZ_CP154876
Coordinates   1685719..1686975 (-) Length   418 a.a.
NCBI ID   WP_000642707.1    Uniprot ID   A0A0B7L5W3
Organism   Streptococcus pneumoniae strain 20155336     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1678849..1700799 1685719..1686975 within 0


Gene organization within MGE regions


Location: 1678849..1700799
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAYT22_RS08650 (AAYT22_08640) - 1678849..1679433 (-) 585 WP_001101186.1 hypothetical protein -
  AAYT22_RS08655 (AAYT22_08645) - 1679831..1680256 (-) 426 WP_001813186.1 hypothetical protein -
  AAYT22_RS08660 (AAYT22_08650) - 1680385..1680744 (-) 360 WP_001813188.1 ImmA/IrrE family metallo-endopeptidase -
  AAYT22_RS08665 (AAYT22_08655) - 1680790..1680996 (-) 207 WP_000366087.1 hypothetical protein -
  AAYT22_RS08670 (AAYT22_08660) - 1680983..1681144 (-) 162 WP_001056001.1 helix-turn-helix domain-containing protein -
  AAYT22_RS08675 (AAYT22_08665) lytA 1681490..1682446 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  AAYT22_RS08680 (AAYT22_08670) - 1682822..1684192 (-) 1371 WP_001036256.1 MATE family efflux transporter -
  AAYT22_RS08685 (AAYT22_08675) recA 1684498..1685664 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  AAYT22_RS08690 (AAYT22_08680) cinA 1685719..1686975 (-) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  AAYT22_RS08695 (AAYT22_08685) brpA 1687060..1688076 (-) 1017 WP_000239286.1 biofilm formation/cell division transcriptional regulator BrpA -
  AAYT22_RS08700 (AAYT22_08690) - 1688084..1688602 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  AAYT22_RS08705 (AAYT22_08695) tsaE 1688592..1689035 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  AAYT22_RS08710 (AAYT22_08700) comM 1689121..1689741 (-) 621 WP_000839908.1 hypothetical protein Regulator
  AAYT22_RS08715 (AAYT22_08705) - 1690124..1690987 (-) 864 WP_001093620.1 helix-turn-helix domain-containing protein -
  AAYT22_RS08720 (AAYT22_08710) - 1691169..1691339 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  AAYT22_RS08725 (AAYT22_08715) pneA1 1691442..1691666 (+) 225 WP_000181086.1 two-peptide bacteriocin subunit PneA1 -
  AAYT22_RS08730 (AAYT22_08720) pneA2 1691673..1691861 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  AAYT22_RS08735 (AAYT22_08725) - 1691977..1694967 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  AAYT22_RS08740 (AAYT22_08730) - 1695317..1696021 (+) 705 WP_001033170.1 flavodoxin family protein -
  AAYT22_RS08745 (AAYT22_08735) - 1696002..1696931 (+) 930 WP_000912951.1 M50 family metallopeptidase -
  AAYT22_RS08750 (AAYT22_08740) - 1696928..1699036 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  AAYT22_RS08755 (AAYT22_08745) - 1699060..1700799 (+) 1740 WP_000699969.1 S8 family peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45061.46 Da        Isoelectric Point: 4.6027

>NTDB_id=994394 AAYT22_RS08690 WP_000642707.1 1685719..1686975(-) (cinA) [Streptococcus pneumoniae strain 20155336]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=994394 AAYT22_RS08690 WP_000642707.1 1685719..1686975(-) (cinA) [Streptococcus pneumoniae strain 20155336]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAACTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L5W3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.761

100

0.998
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.78

100

0.938
  cinA Streptococcus mitis NCTC 12261

93.541

100

0.935
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment