Detailed information NTG0099123

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: SP4011_RS07120
• Genome accession: NZ_AP026968
• Coordinates: 1368964..1369602 (-)
• Length: 212 a.a.
• NCBI ID: WP_000387326.1
• Uniprot ID: -
• Organism: Streptococcus parapneumoniae strain SP4011
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1363964..1374602

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP4011_RS07100 (SP4011_13600)	-	1364565..1365749 (-)	1185	WP_338618507.1	hypothetical protein	-
SP4011_RS07105 (SP4011_13610)	-	1365753..1366340 (-)	588	WP_084588538.1	ATP-binding cassette domain-containing protein	-
SP4011_RS07110 (SP4011_13620)	-	1366373..1366561 (-)	189	WP_338618510.1	hypothetical protein	-
SP4011_RS07115 (SP4011_13630)	comEC/celB	1366740..1368980 (-)	2241	WP_338618512.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SP4011_RS07120 (SP4011_13640)	comEA/celA/cilE	1368964..1369602 (-)	639	WP_000387326.1	helix-hairpin-helix domain-containing protein	Machinery gene
SP4011_RS07125 (SP4011_13650)	-	1369669..1370238 (-)	570	WP_338618513.1	GNAT family N-acetyltransferase	-
SP4011_RS07130 (SP4011_13660)	-	1370345..1371349 (-)	1005	WP_000658197.1	PhoH family protein	-
SP4011_RS07135 (SP4011_13670)	-	1371434..1371649 (-)	216	WP_001232084.1	YozE family protein	-
SP4011_RS07140 (SP4011_13680)	cvfB	1371646..1372512 (-)	867	WP_173229089.1	RNA-binding virulence regulatory protein CvfB	-
SP4011_RS07145 (SP4011_13690)	frr	1372572..1373129 (-)	558	WP_001262225.1	ribosome recycling factor	-
SP4011_RS07150 (SP4011_13700)	pyrH	1373138..1373875 (-)	738	WP_000002996.1	UMP kinase	-

Sequence

Protein

• Length: 212 a.a.
• Molecular weight: 22619.80 Da
• Isoelectric Point: 6.5045

>NTDB_id=99123 SP4011_RS07120 WP_000387326.1 1368964..1369602(-) (comEA/celA/cilE) [Streptococcus parapneumoniae strain SP4011]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPHTPVKETNLQAEVAAVSKDSSTEKEVKEEPVEQDLITVDVKGAVKS
PGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEESASQQAGSGTASSTSKEKKVNLNKASLEE
LKQVKGLGGKRAQDIIDHRESNGKFKSVDELKKVSGIGAKTIEKLKDYVAVD

Nucleotide

• Length: 639 bp

>NTDB_id=99123 SP4011_RS07120 WP_000387326.1 1368964..1369602(-) (comEA/celA/cilE) [Streptococcus parapneumoniae strain SP4011]
ATGGAAGCAATTATCGAGAAAATAAAAGAGTATAAAATCATTGTCATCTGTACTGGTCTGGGCCTGCTTGTTGGCGGATT
TTTCCTACTAAAGCCAGCTCCACACACACCTGTCAAAGAAACGAATTTGCAGGCAGAAGTTGCAGCTGTTTCCAAGGATT
CATCGACCGAAAAGGAAGTGAAGGAAGAACCGGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGTGCTGTCAAATCG
CCAGGAATTTATGACTTGCCCGTAGGTAGTCGGGTCAATGATGCCGTTCAAAAGGCGGGTGGCTTGACAGAGCAAGCAGA
CAGCAAGTCGCTTAATCTAGCTCAGAAAGTTAGTGACGAGGCTCTGGTTTACGTTCCCACTAAGGGAGAAGAATCAGCTA
GTCAGCAGGCAGGTTCTGGGACGGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCCAGTCTGGAAGAG
CTTAAACAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGTCAAATGGGAAATTCAAGTC
AGTAGACGAGCTCAAAAAGGTCTCTGGCATTGGTGCCAAGACTATAGAAAAGTTAAAAGACTATGTTGCAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (72-122)

• Helix-hairpin-helix motif (HHH_3) (147-209)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	93.981	100	0.958
comEA/celA/cilE	Streptococcus mitis NCTC 12261	93.519	100	0.953
comEA/celA/cilE	Streptococcus pneumoniae Rx1	91.204	100	0.929
comEA/celA/cilE	Streptococcus pneumoniae D39	91.204	100	0.929
comEA/celA/cilE	Streptococcus pneumoniae R6	91.204	100	0.929
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.925
comEA	Lactococcus lactis subsp. cremoris KW2	42.081	100	0.439
comEA	Streptococcus thermophilus LMD-9	39.738	100	0.429
comEA	Latilactobacillus sakei subsp. sakei 23K	34.498	100	0.373