Detailed information NTG0099122

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: SP4011_RS07115
• Genome accession: NZ_AP026968
• Coordinates: 1366740..1368980 (-)
• Length: 746 a.a.
• NCBI ID: WP_338618512.1
• Uniprot ID: -
• Organism: Streptococcus parapneumoniae strain SP4011
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1361740..1373980

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP4011_RS07080 (SP4011_13560)	-	1362638..1363018 (-)	381	WP_061759792.1	VOC family protein	-
SP4011_RS07085 (SP4011_13570)	rplT	1363077..1363436 (-)	360	WP_003003310.1	50S ribosomal protein L20	-
SP4011_RS07090 (SP4011_13580)	rpmI	1363488..1363688 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
SP4011_RS07095 (SP4011_13590)	infC	1363721..1364251 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
SP4011_RS07100 (SP4011_13600)	-	1364565..1365749 (-)	1185	WP_338618507.1	hypothetical protein	-
SP4011_RS07105 (SP4011_13610)	-	1365753..1366340 (-)	588	WP_084588538.1	ATP-binding cassette domain-containing protein	-
SP4011_RS07110 (SP4011_13620)	-	1366373..1366561 (-)	189	WP_338618510.1	hypothetical protein	-
SP4011_RS07115 (SP4011_13630)	comEC/celB	1366740..1368980 (-)	2241	WP_338618512.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SP4011_RS07120 (SP4011_13640)	comEA/celA/cilE	1368964..1369602 (-)	639	WP_000387326.1	helix-hairpin-helix domain-containing protein	Machinery gene
SP4011_RS07125 (SP4011_13650)	-	1369669..1370238 (-)	570	WP_338618513.1	GNAT family N-acetyltransferase	-
SP4011_RS07130 (SP4011_13660)	-	1370345..1371349 (-)	1005	WP_000658197.1	PhoH family protein	-
SP4011_RS07135 (SP4011_13670)	-	1371434..1371649 (-)	216	WP_001232084.1	YozE family protein	-
SP4011_RS07140 (SP4011_13680)	cvfB	1371646..1372512 (-)	867	WP_173229089.1	RNA-binding virulence regulatory protein CvfB	-
SP4011_RS07145 (SP4011_13690)	frr	1372572..1373129 (-)	558	WP_001262225.1	ribosome recycling factor	-
SP4011_RS07150 (SP4011_13700)	pyrH	1373138..1373875 (-)	738	WP_000002996.1	UMP kinase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84764.14 Da
• Isoelectric Point: 9.2903

>NTDB_id=99122 SP4011_RS07115 WP_338618512.1 1366740..1368980(-) (comEC/celB) [Streptococcus parapneumoniae strain SP4011]
MLQWIKNFPLPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFFQFSWKSASKVLLLCGIFGFWFLFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKADSRTFQVYYKLQSENEKEQFQVLTDLHEIELEGKLSEPEGQRNFGGFDYQAY
LKTQGIYQTLNIKKIQSLQKVGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVARESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFALSFLYSVIQLNFIFEWLEGMIRLVSQLASRPMVFGQPNVWLLILLLISLALVYDLRKNIKRLAVLSLLITGLFFLTK
HPLENEITMLDVGQGESIFLRDITGKTILIDVGGKAESSKKIEDWQEKVTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVSDLLEVTKAFHIGEILVSKGSLKQKEFVAELQTTQTKVRSVTVGENLPIFGSQLEVLSPRKMGDGGHEDSLVLYGKL
LDKHFLFTGNLEEKGEKELLKKYLDLEVDVLKAGQHGSKNSSSSVFLEQLKPEITLISVGKNNRTKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWKSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=99122 SP4011_RS07115 WP_338618512.1 1366740..1368980(-) (comEC/celB) [Streptococcus parapneumoniae strain SP4011]
ATGTTGCAGTGGATTAAAAATTTCCCCCTTCCCCTAATCTATCTGAGTTTTCTATTGCTCTGGCTTTACTACGCTATTTT
CTCAGCATCCTATCTTGCTTTGTTGGGGTTCGTTTTTCTGCTAGTCTGTCTTTTTTTCCAATTTTCGTGGAAATCAGCTA
GTAAAGTTCTACTGCTTTGCGGAATCTTTGGATTCTGGTTTCTGTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAC
TTAGCGGATTCTGTTGAGAGGGTGCGGATTTTGCCTGACACTATTAAGGTCAATGGTGACAGTCTATCCTTTCGTGGCAA
GGCTGACAGCCGTACCTTCCAAGTTTACTATAAGCTTCAGTCCGAGAATGAAAAAGAACAATTTCAAGTCTTAACAGATC
TTCATGAGATAGAACTTGAAGGAAAACTTTCAGAACCAGAAGGGCAGAGAAATTTTGGTGGTTTTGACTATCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGGTTGGCAGTTGGGATATAGG
TGAAAACCTGTCTAGTTTACGTCGAAAGGCTGTAGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAACTACATGA
CGGGGCTCTTGCTGGGACATCTGGACACAGATTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCTTGTCCGGTATGCAGGTAGGATTTTTCATGGATGGATTTAAGAAGCTTCTTTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATTTATGCAGGGCTGACAGGATTTTCAGCATCGGTCATTCGAAGTC
TCTTGCAGAAGCTACTGGCTCAACATGGGGTTAAAGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATCGTC
ATGCCCAACTTTTTCTTGACAGCAGGAGGTGTCTTGTCCTGCGCCTATGCTTTTATCTTGACCATGACCAGCAAAGAAGG
AGAGGGGCTCAAGGCTGTTGCTAGAGAAAGTCTAGTCATTTCCTTGGGAATATTACCCATTCTATCCTTTTATTTTGCAG
AATTTCAGCCTTGGTCTATTCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGGTTTTCTTACCGCTCTTGTCTATC
TTATTTGCCCTTTCCTTCCTCTATTCAGTCATTCAGCTGAATTTTATTTTTGAATGGTTGGAGGGGATGATTCGCTTGGT
ATCGCAGCTGGCAAGTAGGCCTATGGTCTTTGGACAACCCAATGTATGGCTTTTAATTTTATTGTTAATTTCCTTGGCTT
TAGTCTATGATTTGAGGAAAAACATTAAAAGGCTAGCAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
CATCCACTGGAAAATGAAATTACCATGCTGGATGTGGGGCAAGGCGAAAGTATTTTCCTACGGGATATAACTGGGAAAAC
CATTCTCATAGATGTGGGTGGTAAGGCAGAGTCTAGCAAGAAAATTGAGGATTGGCAAGAAAAGGTGACGACCAGCAATG
CCCAGAGAACCTTGATACCCTATCTCAAAAGTCGAGGAGTAGCCAAGATTGACCAGCTGATTTTGACCAATACGGACAAG
GAACATGTTAGTGATTTGTTGGAGGTGACCAAGGCTTTCCATATAGGTGAAATTTTAGTATCAAAAGGCAGTCTGAAGCA
GAAGGAATTTGTGGCAGAACTACAGACTACTCAAACCAAGGTGCGTAGTGTGACAGTAGGAGAGAACTTGCCAATTTTCG
GAAGCCAGTTAGAAGTCCTATCTCCAAGAAAAATGGGAGATGGAGGTCATGAAGACTCCCTAGTTCTGTATGGAAAACTC
TTGGATAAGCACTTTCTCTTCACTGGAAATTTGGAGGAGAAAGGAGAGAAGGAATTGTTGAAGAAGTATCTTGACCTAGA
AGTGGATGTTTTGAAAGCTGGTCAACATGGTTCTAAAAATTCATCAAGTTCAGTCTTTCTAGAACAGCTCAAACCAGAGA
TCACTCTCATCTCAGTTGGAAAGAACAATCGAACGAAACTACCCCATCAGGAAACCTTGACACGACTGGAAGGTATCAAT
AGCAAAGTATATCGAACTGACCAACAAGGAGCTATACGCTTTAAAGGTTGGAAAAGTTGGAAAATCGAAAGCGTTCGATA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-700)

• Domain of unknown function (DUF4131) (DUF4131) (30-177)

• Competence protein (Competence) (216-458)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	92.895	100	0.929
comEC/celB	Streptococcus mitis NCTC 12261	92.215	99.866	0.921
comEC/celB	Streptococcus pneumoniae TIGR4	91.153	100	0.912
comEC/celB	Streptococcus pneumoniae D39	91.019	100	0.91
comEC/celB	Streptococcus pneumoniae Rx1	91.019	100	0.91
comEC/celB	Streptococcus pneumoniae R6	91.019	100	0.91
comEC	Lactococcus lactis subsp. cremoris KW2	44.804	99.33	0.445