Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   AAFQ93_RS01915 Genome accession   NZ_CP152419
Coordinates   393799..394983 (-) Length   394 a.a.
NCBI ID   WP_000793272.1    Uniprot ID   I2J6S0
Organism   Streptococcus nidrosiense strain SO-23-1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 388799..399983
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAFQ93_RS01895 (AAFQ93_01900) - 389852..390046 (-) 195 WP_000285188.1 DUF951 domain-containing protein -
  AAFQ93_RS01900 (AAFQ93_01905) dnaN 390113..391249 (-) 1137 WP_045762399.1 DNA polymerase III subunit beta -
  AAFQ93_RS01905 (AAFQ93_01910) dnaA 391407..392762 (-) 1356 WP_045762400.1 chromosomal replication initiator protein DnaA -
  AAFQ93_RS01910 (AAFQ93_01915) spo0J 392984..393742 (-) 759 WP_045762401.1 ParB/RepB/Spo0J family partition protein Regulator
  AAFQ93_RS01915 (AAFQ93_01920) htrA 393799..394983 (-) 1185 WP_000793272.1 S1C family serine protease Regulator
  AAFQ93_RS01920 (AAFQ93_01925) rlmH 395167..395646 (+) 480 WP_000695942.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  AAFQ93_RS01930 (AAFQ93_01935) comC 395929..396063 (+) 135 WP_080936286.1 competence-stimulating peptide ComC -
  AAFQ93_RS01935 (AAFQ93_01940) comD 396086..397405 (+) 1320 WP_045762404.1 competence system sensor histidine kinase ComD Regulator
  AAFQ93_RS01940 (AAFQ93_01945) comE 397402..398154 (+) 753 WP_049530388.1 competence system response regulator transcription factor ComE Regulator
  AAFQ93_RS01950 (AAFQ93_01955) - 398561..399103 (-) 543 WP_001158257.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 394 a.a.        Molecular weight: 41493.44 Da        Isoelectric Point: 5.4511

>NTDB_id=989150 AAFQ93_RS01915 WP_000793272.1 393799..394983(-) (htrA) [Streptococcus nidrosiense strain SO-23-1]
MKNLKTSSKKWGQLLVVILISFFSGILGTFTTLQLSQKQNSGTTTTTTVSKTAVKNENSTTQAVDKVKDAVVSVITYSSN
SQNSLLGSDETDTDTNAEQVYSEGSGVIYKKEGDTAYLVTNTHVINGAKKVDIRLADGTKVPGEIVGSDTYSDIAVVKIA
ADKVTTVAEFGDSSQLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTNAIQTDTAINPGNSGGPLI
NIQGQVIGITSSKIASNGGTSVEGLGFAIPANDVINIIKQLEKDGKVTRPALGIHMVNLSNLSTTDLQKLKLPGNVTSGV
AVRSVQKNMPANGHLQQYDVITKIDDKAISSTTELQSALYSHSIGDSMTVTYYRDGKEETTTIKLDKSTSDLDK

Nucleotide


Download         Length: 1185 bp        

>NTDB_id=989150 AAFQ93_RS01915 WP_000793272.1 393799..394983(-) (htrA) [Streptococcus nidrosiense strain SO-23-1]
ATGAAAAACTTAAAAACTAGTTCCAAAAAATGGGGACAACTTTTAGTAGTCATTCTCATTAGCTTTTTTAGTGGTATTTT
AGGTACTTTTACCACATTGCAGCTCAGTCAAAAACAAAATAGTGGTACGACAACTACAACGACTGTCAGCAAAACAGCTG
TAAAAAATGAAAACTCAACTACTCAAGCAGTTGATAAAGTTAAAGATGCTGTTGTATCTGTCATTACTTACTCATCAAAC
TCTCAAAACAGTTTACTCGGATCTGATGAAACTGATACAGATACCAATGCTGAACAAGTATACAGTGAAGGTTCTGGTGT
CATTTATAAAAAGGAAGGGGATACTGCTTACCTTGTAACCAATACTCACGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTAGCAGATGGTACAAAAGTCCCTGGTGAAATTGTGGGTTCTGATACTTATTCAGATATTGCCGTTGTAAAAATTGCT
GCAGATAAGGTCACAACAGTAGCCGAATTTGGTGATTCTAGTCAACTAACAGTTGGAGAAACAGCTATTGCAATCGGAAG
TCCTCTAGGTTCTGAATATGCCAATACTGTGACACAGGGGATTGTATCAAGTTTAAATAGAAATGTATCTCTAAAATCTG
AAGACGGACAAGCTATCTCAACTAATGCTATCCAAACAGATACAGCTATTAACCCTGGGAACTCAGGTGGTCCTTTGATT
AATATCCAAGGCCAAGTCATCGGTATTACATCAAGTAAAATTGCCTCTAATGGTGGAACATCTGTCGAAGGTCTCGGTTT
TGCCATTCCTGCAAACGATGTAATTAATATTATTAAGCAGTTGGAAAAAGATGGAAAAGTAACTCGACCTGCTCTTGGAA
TCCACATGGTTAACTTATCAAATCTTAGTACAACTGATCTTCAAAAACTAAAACTTCCTGGAAATGTTACTTCTGGTGTA
GCTGTTCGTTCTGTTCAAAAAAATATGCCTGCCAATGGACATCTGCAACAATATGACGTCATTACAAAAATAGATGATAA
AGCTATTTCTTCCACTACTGAATTGCAAAGTGCTCTATATAGTCATTCTATTGGAGACAGTATGACTGTTACTTACTACC
GTGATGGTAAGGAAGAAACAACAACTATTAAATTAGATAAAAGTACTAGTGATTTAGATAAGTAG

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(290-385)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I2J6S0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

78.173

100

0.782
  htrA Streptococcus pneumoniae Rx1

77.919

100

0.779
  htrA Streptococcus pneumoniae D39

77.919

100

0.779
  htrA Streptococcus pneumoniae R6

77.919

100

0.779
  htrA Streptococcus pneumoniae TIGR4

77.919

100

0.779
  htrA Streptococcus gordonii str. Challis substr. CH1

68.421

100

0.693
  htrA Streptococcus mutans UA159

54.337

99.492

0.541

Multiple sequence alignment