Detailed information NTG0989116

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AAHH81_RS10370
• Genome accession: NZ_CP152418
• Coordinates: 2025215..2025967 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 20234287
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2020215..2030967

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAHH81_RS10350 (AAHH81_10335)	-	2022648..2024251 (-)	1604	Protein_1998	YhgE/Pip family protein	-
AAHH81_RS10355 (AAHH81_10340)	-	2024430..2024972 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AAHH81_RS10370 (AAHH81_10355)	comE	2025215..2025967 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AAHH81_RS10375 (AAHH81_10360)	comD/comD1	2025964..2027289 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
AAHH81_RS10380 (AAHH81_10365)	comC/comC1	2027310..2027435 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AAHH81_RS10390 (AAHH81_10375)	rlmH	2027717..2028196 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AAHH81_RS10395 (AAHH81_10380)	htrA	2028379..2029560 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
AAHH81_RS10400 (AAHH81_10385)	spo0J	2029618..2030376 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=989116 AAHH81_RS10370 WP_000866065.1 2025215..2025967(-) (comE) [Streptococcus pneumoniae strain 20234287]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=989116 AAHH81_RS10370 WP_000866065.1 2025215..2025967(-) (comE) [Streptococcus pneumoniae strain 20234287]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408