Detailed information NTG0098233

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: R8625_RS10925
• Genome accession: NZ_AP026923
• Coordinates: 2094259..2095011 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700054
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2089259..2100011

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8625_RS10905	-	2091734..2093346 (-)	1613	Protein_2107	YhgE/Pip family protein	-
R8625_RS10910 (PC0054_21100)	-	2093474..2094016 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
R8625_RS10925 (PC0054_21110)	comE	2094259..2095011 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
R8625_RS10930 (PC0054_21120)	comD/comD1	2095008..2096333 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
R8625_RS10935 (PC0054_21130)	comC/comC1	2096354..2096479 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
R8625_RS10945 (PC0054_21140)	rlmH	2096761..2097240 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
R8625_RS10950 (PC0054_21150)	htrA	2097423..2098604 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
R8625_RS10955 (PC0054_21160)	spo0J	2098662..2099420 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=98233 R8625_RS10925 WP_000866065.1 2094259..2095011(-) (comE) [Streptococcus pneumoniae strain PZ900700054]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=98233 R8625_RS10925 WP_000866065.1 2094259..2095011(-) (comE) [Streptococcus pneumoniae strain PZ900700054]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408