Detailed information NTG0098179

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: R8625_RS04390
• Genome accession: NZ_AP026923
• Coordinates: 862733..863383 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387336.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700054
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 857733..868383

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8625_RS04360 (PC0054_08620)	pyrH	858457..859194 (+)	738	WP_000002997.1	UMP kinase	-
R8625_RS04365 (PC0054_08630)	frr	859203..859760 (+)	558	WP_000024409.1	ribosome recycling factor	-
R8625_RS04370 (PC0054_08640)	cvfB	859820..860674 (+)	855	WP_317649393.1	RNA-binding virulence regulatory protein CvfB	-
R8625_RS04375 (PC0054_08650)	-	860683..860898 (+)	216	WP_001232085.1	YozE family protein	-
R8625_RS04380 (PC0054_08660)	-	860984..861988 (+)	1005	WP_000658185.1	PhoH family protein	-
R8625_RS04385 (PC0054_08670)	-	862096..862665 (+)	570	WP_000443751.1	GNAT family N-acetyltransferase	-
R8625_RS04390 (PC0054_08680)	comEA/celA/cilE	862733..863383 (+)	651	WP_000387336.1	ComEA family DNA-binding protein	Machinery gene
R8625_RS04395 (PC0054_08690)	comEC/celB	863367..865607 (+)	2241	WP_023396235.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
R8625_RS04400 (PC0054_08700)	-	865786..865974 (+)	189	WP_023396236.1	hypothetical protein	-
R8625_RS04405 (PC0054_08710)	-	866006..866593 (+)	588	WP_000933542.1	ATP-binding cassette domain-containing protein	-
R8625_RS04410 (PC0054_08720)	-	866597..867778 (+)	1182	WP_000655945.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23189.54 Da
• Isoelectric Point: 5.5171

>NTDB_id=98179 R8625_RS04390 WP_000387336.1 862733..863383(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700054]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=98179 R8625_RS04390 WP_000387336.1 862733..863383(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700054]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae D39	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae R6	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.222	100	0.972
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis SK321	91.204	100	0.912
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361