Detailed information NTG0097610

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: R8775_RS10695
• Genome accession: NZ_AP026915
• Coordinates: 2052312..2053064 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700005
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2047312..2058064

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8775_RS10675	-	2049746..2051399 (-)	1654	Protein_2069	YhgE/Pip family protein	-
R8775_RS10680 (PC0005_20660)	-	2051527..2052069 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
R8775_RS10695 (PC0005_20670)	comE	2052312..2053064 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
R8775_RS10700 (PC0005_20680)	comD/comD1	2053061..2054386 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
R8775_RS10705 (PC0005_20690)	comC/comC1	2054407..2054532 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
R8775_RS10715 (PC0005_20700)	rlmH	2054814..2055293 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
R8775_RS10720 (PC0005_20710)	htrA	2055476..2056657 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
R8775_RS10725 (PC0005_20720)	spo0J	2056715..2057473 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=97610 R8775_RS10695 WP_000866065.1 2052312..2053064(-) (comE) [Streptococcus pneumoniae strain PZ900700005]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=97610 R8775_RS10695 WP_000866065.1 2052312..2053064(-) (comE) [Streptococcus pneumoniae strain PZ900700005]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408