Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP/pknB   Type   Regulator
Locus tag   WMY90_RS04605 Genome accession   NZ_CP150875
Coordinates   905022..906893 (-) Length   623 a.a.
NCBI ID   WP_002946880.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain TCI125     
Function   activate comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 903257..969705 905022..906893 within 0


Gene organization within MGE regions


Location: 903257..969705
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WMY90_RS04595 (WMY90_04595) liaF 903265..903963 (-) 699 WP_011226289.1 cell wall-active antibiotics response protein LiaF -
  WMY90_RS04600 (WMY90_04600) - 904218..904385 (-) 168 WP_232089277.1 ion channel -
  WMY90_RS04605 (WMY90_04605) stkP/pknB 905022..906893 (-) 1872 WP_002946880.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  WMY90_RS04610 (WMY90_04610) - 906893..907630 (-) 738 WP_002946881.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  WMY90_RS04615 (WMY90_04615) rsmB 907674..908996 (-) 1323 WP_014608533.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  WMY90_RS04620 (WMY90_04620) fmt 908986..909921 (-) 936 WP_002946883.1 methionyl-tRNA formyltransferase -
  WMY90_RS04625 (WMY90_04625) - 909939..912335 (-) 2397 WP_176243306.1 primosomal protein N' -
  WMY90_RS04630 (WMY90_04630) rpoZ 912477..912791 (-) 315 WP_002951415.1 DNA-directed RNA polymerase subunit omega -
  WMY90_RS04635 (WMY90_04635) gmk 912813..913442 (-) 630 WP_022096878.1 guanylate kinase -
  WMY90_RS04640 (WMY90_04640) ftsY 913675..915066 (-) 1392 WP_011681410.1 signal recognition particle-docking protein FtsY -
  WMY90_RS04645 (WMY90_04645) - 915077..915895 (-) 819 WP_011681411.1 Cof-type HAD-IIB family hydrolase -
  WMY90_RS04650 (WMY90_04650) - 915888..916682 (-) 795 WP_022096877.1 HAD family hydrolase -
  WMY90_RS04655 (WMY90_04655) - 916866..917243 (+) 378 WP_011226300.1 GntR family transcriptional regulator -
  WMY90_RS04660 (WMY90_04660) - 917248..917946 (+) 699 WP_022096876.1 ABC transporter ATP-binding protein -
  WMY90_RS04665 (WMY90_04665) - 917958..918743 (+) 786 WP_002951425.1 hypothetical protein -
  WMY90_RS04670 (WMY90_04670) amiF 918793..919722 (-) 930 WP_002951426.1 ATP-binding cassette domain-containing protein Regulator
  WMY90_RS04675 (WMY90_04675) amiE 919715..920800 (-) 1086 WP_002946408.1 ABC transporter ATP-binding protein Regulator
  WMY90_RS04680 (WMY90_04680) amiD 920810..921736 (-) 927 WP_002946409.1 oligopeptide ABC transporter permease OppC Regulator
  WMY90_RS04685 (WMY90_04685) amiC 921736..923229 (-) 1494 WP_260215011.1 ABC transporter permease Regulator
  WMY90_RS04690 (WMY90_04690) amiA 923291..925258 (-) 1968 WP_096811568.1 peptide ABC transporter substrate-binding protein Regulator
  WMY90_RS04695 (WMY90_04695) - 925462..925652 (-) 191 Protein_921 IS3 family transposase -
  WMY90_RS04700 (WMY90_04700) amiF 925643..925813 (-) 171 WP_014608546.1 hypothetical protein Regulator
  WMY90_RS04705 (WMY90_04705) amiF 925826..926062 (-) 237 WP_308123564.1 ABC transporter ATP-binding protein Regulator
  WMY90_RS04710 (WMY90_04710) - 926042..926402 (-) 361 Protein_924 TatD family hydrolase -
  WMY90_RS04715 (WMY90_04715) - 926751..927956 (+) 1206 WP_011227415.1 OFA family MFS transporter -
  WMY90_RS04720 (WMY90_04720) - 928002..929355 (-) 1354 Protein_926 IS3 family transposase -
  WMY90_RS04725 (WMY90_04725) pta 929441..930424 (-) 984 WP_022097032.1 phosphate acetyltransferase -
  WMY90_RS04730 (WMY90_04730) - 930438..931334 (-) 897 WP_011226316.1 RluA family pseudouridine synthase -
  WMY90_RS04735 (WMY90_04735) - 931331..932167 (-) 837 WP_022097031.1 NAD kinase -
  WMY90_RS04740 (WMY90_04740) - 932139..932813 (-) 675 WP_002951443.1 GTP pyrophosphokinase family protein -
  WMY90_RS04745 (WMY90_04745) - 932909..933484 (+) 576 WP_002951444.1 CYTH domain-containing protein -
  WMY90_RS04750 (WMY90_04750) - 933847..934818 (+) 972 WP_260215000.1 ribose-phosphate diphosphokinase -
  WMY90_RS04755 (WMY90_04755) - 934822..935934 (+) 1113 WP_002948029.1 cysteine desulfurase family protein -
  WMY90_RS04760 (WMY90_04760) - 935936..936283 (+) 348 WP_002948028.1 DUF1831 domain-containing protein -
  WMY90_RS04765 (WMY90_04765) - 936427..937086 (+) 660 WP_002948027.1 redox-sensing transcriptional repressor Rex -
  WMY90_RS04770 (WMY90_04770) - 937079..937774 (+) 696 WP_002948026.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
  WMY90_RS04775 (WMY90_04775) radC 937827..938513 (-) 687 WP_002948025.1 DNA repair protein RadC -
  WMY90_RS04780 (WMY90_04780) - 938562..940346 (-) 1785 WP_002948024.1 rhamnan synthesis F family protein -
  WMY90_RS04785 (WMY90_04785) - 940343..941398 (-) 1056 WP_002948022.1 glycosyltransferase -
  WMY90_RS04790 (WMY90_04790) - 941418..942623 (-) 1206 WP_014727633.1 ABC transporter ATP-binding protein -
  WMY90_RS04795 (WMY90_04795) - 942623..943432 (-) 810 WP_002948020.1 ABC transporter permease -
  WMY90_RS04800 (WMY90_04800) - 943416..944372 (-) 957 WP_014727634.1 glycosyltransferase family 2 protein -
  WMY90_RS04805 (WMY90_04805) - 944369..945517 (-) 1149 WP_002948014.1 glycosyltransferase family 1 protein -
  WMY90_RS04810 (WMY90_04810) - 945626..946636 (-) 1011 WP_022097029.1 glycosyltransferase family A protein -
  WMY90_RS04815 (WMY90_04815) - 946636..947910 (-) 1275 WP_022097028.1 polysaccharide biosynthesis protein transporter -
  WMY90_RS04820 (WMY90_04820) - 947903..948235 (-) 333 WP_011226332.1 DUF2304 domain-containing protein -
  WMY90_RS04825 (WMY90_04825) - 948241..948936 (-) 696 WP_173940715.1 glycosyltransferase family 2 protein -
  WMY90_RS04830 (WMY90_04830) rfbD 949013..949864 (-) 852 WP_022097027.1 dTDP-4-dehydrorhamnose reductase -
  WMY90_RS04835 (WMY90_04835) - 949941..951275 (-) 1335 WP_002946422.1 DUF6056 family protein -
  WMY90_RS04840 (WMY90_04840) - 951388..952308 (-) 921 WP_116920321.1 glycosyltransferase family 2 protein -
  WMY90_RS04845 (WMY90_04845) - 952368..953783 (-) 1416 WP_022097026.1 DUF2142 domain-containing protein -
  WMY90_RS04850 (WMY90_04850) - 954117..954452 (-) 336 WP_002891474.1 metal-sulfur cluster assembly factor -
  WMY90_RS04855 (WMY90_04855) rpoD 954506..955615 (-) 1110 WP_011226338.1 RNA polymerase sigma factor RpoD -
  WMY90_RS04860 (WMY90_04860) dnaG 955619..957430 (-) 1812 WP_011681448.1 DNA primase -
  WMY90_RS04865 (WMY90_04865) mscL 957571..957654 (+) 84 Protein_955 large conductance mechanosensitive channel protein MscL -
  WMY90_RS04870 (WMY90_04870) rpsU 957814..957990 (-) 177 WP_082309068.1 30S ribosomal protein S21 -
  WMY90_RS04875 (WMY90_04875) - 958185..958979 (-) 795 WP_022097025.1 ABC transporter substrate-binding protein -
  WMY90_RS04880 (WMY90_04880) - 959041..960150 (-) 1110 WP_022097024.1 aminotransferase -
  WMY90_RS04885 (WMY90_04885) - 960497..961294 (-) 798 WP_022097023.1 transporter substrate-binding domain-containing protein -
  WMY90_RS04890 (WMY90_04890) - 961291..962121 (-) 831 WP_022097022.1 transporter substrate-binding domain-containing protein -
  WMY90_RS04895 (WMY90_04895) - 962335..962799 (-) 465 WP_011681454.1 8-oxo-dGTP diphosphatase -
  WMY90_RS04900 (WMY90_04900) uvrB 962844..964835 (-) 1992 WP_002953358.1 excinuclease ABC subunit UvrB -
  WMY90_RS04905 (WMY90_04905) - 964982..965449 (-) 468 WP_022097021.1 hypothetical protein -
  WMY90_RS04910 (WMY90_04910) - 965522..966458 (-) 937 Protein_964 type II CAAX endopeptidase family protein -
  WMY90_RS04915 (WMY90_04915) - 966657..968867 (+) 2211 WP_173940613.1 ABC transporter substrate-binding protein/permease -
  WMY90_RS04920 (WMY90_04920) - 968867..969607 (+) 741 WP_002945131.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 623 a.a.        Molecular weight: 67861.71 Da        Isoelectric Point: 6.7921

>NTDB_id=973220 WMY90_RS04605 WP_002946880.1 905022..906893(-) (stkP/pknB) [Streptococcus thermophilus strain TCI125]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVPSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVIGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPAAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSLNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
DPQVGTAVDGTVILYVSVVTKSSSIQQSSSASTTQSPSSTSSSSESSTASSTETDTEATHTEQ

Nucleotide


Download         Length: 1872 bp        

>NTDB_id=973220 WMY90_RS04605 WP_002946880.1 905022..906893(-) (stkP/pknB) [Streptococcus thermophilus strain TCI125]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTCCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTATAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTGCAGCTGGGACAATGCGTAAAGAAGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCCTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGTAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACAGAGGTCCTTTATCAA
GATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCTCAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGATACAGAAGCTACTCACACAGAGCAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(508-577)

PASTA domain (PASTA)

(367-429)

PASTA domain (PASTA)

(436-502)

Protein kinase domain (Pkinase)

(12-235)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP/pknB Streptococcus salivarius strain HSISS4

90.189

93.258

0.841
  pknB Streptococcus mutans UA159

64.522

87.319

0.563
  stkP Streptococcus pneumoniae TIGR4

58.045

78.812

0.457
  stkP Streptococcus pneumoniae D39

57.841

78.812

0.456
  stkP Streptococcus pneumoniae R6

57.841

78.812

0.456
  stkP Streptococcus pneumoniae Rx1

57.637

78.812

0.454

Multiple sequence alignment