Detailed information NTG0096266

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AABJ45_RS11470
• Genome accession: NZ_AP028611
• Coordinates: 2238336..2239073 (-)
• Length: 245 a.a.
• NCBI ID: WP_338372085.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Sep6
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2233336..2244073

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABJ45_RS11445	-	2234510..2236112 (-)	1603	Protein_2218	YhgE/Pip domain-containing protein	-
AABJ45_RS11450 (TKY121527_22350)	-	2236291..2236833 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AABJ45_RS11465 (TKY121527_22360)	-	2237380..2238333 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
AABJ45_RS11470 (TKY121527_22370)	comE	2238336..2239073 (-)	738	WP_338372085.1	competence system response regulator transcription factor ComE	Regulator
AABJ45_RS11475 (TKY121527_22380)	comD/comD2	2239070..2240395 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
AABJ45_RS11480	comC/comC2	2240416..2240541 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
AABJ45_RS11490 (TKY121527_22390)	rlmH	2240823..2241302 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AABJ45_RS11495 (TKY121527_22400)	htrA	2241485..2242666 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
AABJ45_RS11500 (TKY121527_22410)	spo0J	2242724..2243482 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 29304.49 Da
• Isoelectric Point: 6.1046

>NTDB_id=96266 AABJ45_RS11470 WP_338372085.1 2238336..2239073(-) (comE) [Streptococcus pneumoniae strain Sep6]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVVQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
TQISS

Nucleotide

• Length: 738 bp

>NTDB_id=96266 AABJ45_RS11470 WP_338372085.1 2238336..2239073(-) (comE) [Streptococcus pneumoniae strain Sep6]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGTTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
ACCCAAATTTCAAGTTGA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-243)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	98.765	99.184	0.98
comE	Streptococcus pneumoniae D39	98.765	99.184	0.98
comE	Streptococcus pneumoniae R6	98.765	99.184	0.98
comE	Streptococcus pneumoniae TIGR4	98.765	99.184	0.98
comE	Streptococcus mitis SK321	97.942	99.184	0.971
comE	Streptococcus mitis NCTC 12261	97.119	99.184	0.963
comE	Streptococcus infantis strain Atu-4	90.535	99.184	0.898
comE/comE2	Streptococcus gordonii strain NCTC7865	62.14	99.184	0.616
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.14	99.184	0.616
comE/blpR	Streptococcus mutans UA159	41.057	100	0.412