Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   QML87_RS08630 Genome accession   NZ_AP025936
Coordinates   1702147..1703403 (-) Length   418 a.a.
NCBI ID   WP_000642706.1    Uniprot ID   A0A098Z3K2
Organism   Streptococcus pneumoniae strain PZ900700617     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1695031..1717236 1702147..1703403 within 0


Gene organization within MGE regions


Location: 1695031..1717236
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QML87_RS08590 (PC0607_16900) - 1695031..1695825 (-) 795 WP_001101210.1 hypothetical protein -
  QML87_RS08595 (PC0607_16910) - 1696233..1696658 (-) 426 WP_000204065.1 hypothetical protein -
  QML87_RS08600 (PC0607_16920) - 1696787..1697146 (-) 360 WP_000749822.1 hypothetical protein -
  QML87_RS08605 (PC0607_16930) - 1697192..1697398 (-) 207 WP_000366091.1 hypothetical protein -
  QML87_RS08610 (PC0607_16940) - 1697385..1697558 (-) 174 WP_000289349.1 helix-turn-helix transcriptional regulator -
  QML87_RS08615 (PC0607_16950) lytA 1697917..1698873 (-) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  QML87_RS08620 (PC0607_16960) - 1699249..1700619 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  QML87_RS08625 (PC0607_16970) recA 1700926..1702092 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  QML87_RS08630 (PC0607_16980) cinA 1702147..1703403 (-) 1257 WP_000642706.1 competence/damage-inducible protein A Machinery gene
  QML87_RS08635 (PC0607_16990) - 1703488..1704504 (-) 1017 WP_000239282.1 LCP family protein -
  QML87_RS08640 (PC0607_17000) - 1704512..1705030 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  QML87_RS08645 (PC0607_17010) tsaE 1705020..1705463 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  QML87_RS08650 (PC0607_17020) comM 1705549..1706169 (-) 621 WP_000839908.1 hypothetical protein Regulator
  QML87_RS08655 (PC0607_17030) - 1706552..1707415 (-) 864 WP_001093641.1 helix-turn-helix transcriptional regulator -
  QML87_RS08660 (PC0607_17040) - 1707607..1707777 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  QML87_RS08665 (PC0607_17050) pneA1 1707880..1708104 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  QML87_RS08670 (PC0607_17060) pneA2 1708111..1708299 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  QML87_RS08675 (PC0607_17070) lanM 1708414..1711404 (+) 2991 WP_000875573.1 type 2 lanthipeptide synthetase LanM -
  QML87_RS08680 (PC0607_17080) - 1711754..1712458 (+) 705 WP_001033170.1 flavodoxin family protein -
  QML87_RS08685 (PC0607_17090) - 1712439..1713368 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  QML87_RS08690 (PC0607_17100) - 1713365..1715473 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  QML87_RS08695 (PC0607_17110) - 1715497..1717236 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45062.40 Da        Isoelectric Point: 4.5211

>NTDB_id=95225 QML87_RS08630 WP_000642706.1 1702147..1703403(-) (cinA) [Streptococcus pneumoniae strain PZ900700617]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=95225 QML87_RS08630 WP_000642706.1 1702147..1703403(-) (cinA) [Streptococcus pneumoniae strain PZ900700617]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A098Z3K2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

99.761

100

0.998
  cinA Streptococcus pneumoniae R6

99.761

100

0.998
  cinA Streptococcus pneumoniae TIGR4

99.522

100

0.995
  cinA Streptococcus pneumoniae D39

99.522

100

0.995
  cinA Streptococcus mitis SK321

93.541

100

0.935
  cinA Streptococcus mitis NCTC 12261

93.301

100

0.933
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment