Detailed information NTG0092509

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: Llc71_RS08290
• Genome accession: NZ_AP025520
• Coordinates: 1669748..1670440 (-)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain 7-1
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1664748..1675440

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Llc71_RS08270 (Llc71_16580)	murD	1664895..1666244 (-)	1350	WP_248536584.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
Llc71_RS08275 (Llc71_16590)	-	1666413..1666754 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
Llc71_RS08280 (Llc71_16600)	-	1666836..1668077 (-)	1242	WP_046124518.1	ammonium transporter	-
Llc71_RS08285 (Llc71_16610)	covS	1668263..1669735 (-)	1473	WP_046124519.1	HAMP domain-containing histidine kinase	Regulator
Llc71_RS08290 (Llc71_16620)	covR	1669748..1670440 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
Llc71_RS08295 (Llc71_16630)	-	1670597..1671127 (-)	531	WP_046124520.1	DUF177 domain-containing protein	-
Llc71_RS08300 (Llc71_16640)	-	1671260..1671505 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
Llc71_RS08305 (Llc71_16650)	-	1671829..1672191 (-)	363	WP_046124521.1	TIGR02328 family protein	-
Llc71_RS08310 (Llc71_16660)	-	1672427..1673338 (-)	912	WP_043735255.1	CHAP domain-containing protein	-
Llc71_RS08315 (Llc71_16670)	-	1673431..1674267 (-)	837	WP_248536585.1	metallophosphoesterase	-
Llc71_RS08320 (Llc71_16680)	arsC	1674379..1674783 (-)	405	WP_021037563.1	arsenate reductase (thioredoxin)	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=92509 Llc71_RS08290 WP_011676631.1 1669748..1670440(-) (covR) [Lactococcus cremoris strain 7-1]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=92509 Llc71_RS08290 WP_011676631.1 1669748..1670440(-) (covR) [Lactococcus cremoris strain 7-1]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGTCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCACGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTCTGACGTTGATGCAAAATGTTGGAGACGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361