Detailed information NTG0903497

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SHN03_RS09665
• Genome accession: NZ_CP138566
• Coordinates: 1985569..1986612 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017129.1
• Uniprot ID: A0A0U1MRG1
• Organism: Staphylococcus aureus strain AUSMDU00020487
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1980569..1991612

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SHN03_RS09635	-	1980917..1981117 (-)	201	WP_001813025.1	DUF1128 family protein	-
SHN03_RS09640	-	1981264..1981728 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SHN03_RS09645	-	1981735..1982010 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SHN03_RS09650	-	1982298..1983470 (-)	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
SHN03_RS09655	-	1983620..1984837 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
SHN03_RS09660	vraR	1984950..1985579 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SHN03_RS09665	vraS	1985569..1986612 (-)	1044	WP_001017129.1	sensor histidine kinase	Regulator
SHN03_RS09670	liaF	1986609..1987310 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SHN03_RS09675	-	1987325..1987711 (-)	387	WP_001110183.1	hypothetical protein	-
SHN03_RS09680	map	1987928..1988686 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
SHN03_RS09685	-	1989329..1990315 (+)	987	WP_000999711.1	FUSC family protein	-
SHN03_RS09690	-	1990491..1990907 (-)	417	WP_025174454.1	hypothetical protein	-
SHN03_RS09695	-	1990936..1991045 (-)	110	Protein_1873	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40060.56 Da
• Isoelectric Point: 6.0577

>NTDB_id=903497 SHN03_RS09665 WP_001017129.1 1985569..1986612(-) (vraS) [Staphylococcus aureus strain AUSMDU00020487]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQILILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=903497 SHN03_RS09665 WP_001017129.1 1985569..1986612(-) (vraS) [Staphylococcus aureus strain AUSMDU00020487]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCT
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCGAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0U1MRG1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997