Detailed information NTG0896156

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R4701_RS02595
• Genome accession: NZ_CP137114
• Coordinates: 518435..519022 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 15P3054
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 513435..524022

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4701_RS02555	-	513688..514377 (-)	690	WP_000760515.1	CPBP family intramembrane glutamic endopeptidase	-
R4701_RS02560	-	514429..514812 (-)	384	WP_000877381.1	hypothetical protein	-
R4701_RS02565	-	515441..515799 (-)	359	Protein_509	immunity protein	-
R4701_RS02570	-	516280..516399 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R4701_RS02575	cipB	516503..516652 (-)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
R4701_RS02580	blpK	516896..517144 (-)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
R4701_RS02585	blpJ	517213..517482 (-)	270	WP_001093250.1	bacteriocin-like peptide BlpJ	-
R4701_RS02590	blpI	517949..518146 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
R4701_RS02595	comA/nlmT	518435..519022 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R4701_RS02600	comA/nlmT	518967..519773 (+)	807	WP_317805977.1	ABC transporter transmembrane domain-containing protein	Regulator
R4701_RS02605	comA/nlmT	519810..520592 (+)	783	WP_317805978.1	ATP-binding cassette domain-containing protein	Regulator
R4701_RS02610	-	520603..521964 (+)	1362	WP_001069085.1	bacteriocin secretion accessory protein	-
R4701_RS02615	blpC	522021..522176 (+)	156	WP_000358810.1	quorum-sensing system pheromone BlpC	-
R4701_RS02620	-	522221..523561 (-)	1341	WP_317805979.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=896156 R4701_RS02595 WP_000205166.1 518435..519022(+) (comA/nlmT) [Streptococcus pneumoniae strain 15P3054]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=896156 R4701_RS02595 WP_000205166.1 518435..519022(+) (comA/nlmT) [Streptococcus pneumoniae strain 15P3054]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497