Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA   Type   Machinery gene
Locus tag   AAF758_RS00755 Genome accession   NZ_CP152119
Coordinates   119729..120679 (+) Length   316 a.a.
NCBI ID   WP_011921718.1    Uniprot ID   A0A0H3MX74
Organism   Streptococcus suis strain Ss2301     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 114729..125679
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAF758_RS00745 (AAF758_00745) - 118300..118665 (+) 366 WP_002936568.1 DUF1033 family protein -
  AAF758_RS00750 (AAF758_00750) - 118700..119643 (-) 944 Protein_113 S66 peptidase family protein -
  AAF758_RS00755 (AAF758_00755) comGA 119729..120679 (+) 951 WP_011921718.1 competence type IV pilus ATPase ComGA Machinery gene
  AAF758_RS00760 (AAF758_00760) comGB 120591..121628 (+) 1038 WP_011921719.1 competence type IV pilus assembly protein ComGB Machinery gene
  AAF758_RS00765 (AAF758_00765) comGC 121630..121911 (+) 282 WP_011921720.1 competence type IV pilus major pilin ComGC Machinery gene
  AAF758_RS00770 (AAF758_00770) comGD 121892..122299 (+) 408 WP_011921721.1 competence type IV pilus minor pilin ComGD Machinery gene
  AAF758_RS00775 (AAF758_00775) comGE 122271..122564 (+) 294 WP_011921722.1 competence type IV pilus minor pilin ComGE Machinery gene
  AAF758_RS00780 (AAF758_00780) comGF/cglF 122551..122985 (+) 435 WP_011922561.1 competence type IV pilus minor pilin ComGF Machinery gene
  AAF758_RS00785 (AAF758_00785) comGG 122963..123373 (+) 411 WP_011921724.1 competence type IV pilus minor pilin ComGG Machinery gene
  AAF758_RS00790 (AAF758_00790) comGH 123430..124383 (+) 954 WP_011922562.1 class I SAM-dependent methyltransferase Machinery gene
  AAF758_RS00795 (AAF758_00795) - 124433..125620 (+) 1188 WP_012775422.1 acetate kinase -

Sequence

Protein


Download         Length: 316 a.a.        Molecular weight: 35412.26 Da        Isoelectric Point: 5.4713

>NTDB_id=891597 AAF758_RS00755 WP_011921718.1 119729..120679(+) (comGA) [Streptococcus suis strain Ss2301]
MIQEKARKMIEEAVADRVSDIYLVPRGECYQVYHRIMDDREFVQDLAEEEVTAIISHFKFLAGLNVGEKRRSQQGSCDYD
YGSGEISLRLSTVGDYRGKESLVIRLLYDNDKELKFWFEAAERLAEEIKGRGLYLFSGPVGSGKTTLMYHLARLKFPDKQ
ILTIEDPVEIKQEDMLQLQLNEAIGATYDNLIKLSLRHRPDLLIIGEIRDAETARAVIRASLTGATVFSTVHARSISGVY
ARMLELGVGPEELNNALQGIAYQRLIGGGGVVDFAKGNYQNHSADQWNAQIDRLFAAGHISLRQAETEKITLGSPA

Nucleotide


Download         Length: 951 bp        

>NTDB_id=891597 AAF758_RS00755 WP_011921718.1 119729..120679(+) (comGA) [Streptococcus suis strain Ss2301]
ATGATTCAAGAAAAAGCAAGAAAGATGATTGAAGAGGCGGTGGCGGATAGGGTCAGTGACATTTATCTGGTTCCTCGTGG
TGAGTGTTACCAAGTCTATCATCGTATCATGGACGATCGGGAATTTGTGCAAGACTTGGCTGAGGAGGAAGTAACAGCCA
TCATCAGCCATTTCAAGTTTTTAGCAGGTTTAAATGTTGGCGAAAAACGCCGTAGCCAGCAGGGTTCCTGTGACTATGAT
TATGGGAGCGGAGAGATTTCACTTCGCTTATCAACTGTCGGAGATTATCGTGGCAAGGAAAGTTTGGTTATCCGCCTGCT
CTATGACAATGACAAGGAACTCAAGTTCTGGTTTGAGGCGGCCGAGCGGCTTGCAGAAGAAATCAAGGGACGAGGGCTCT
ACCTTTTTTCGGGTCCAGTCGGCTCTGGTAAGACCACACTTATGTACCATCTTGCTAGGCTGAAATTCCCAGACAAGCAG
ATTTTGACCATCGAGGATCCTGTTGAAATCAAGCAGGAGGACATGCTGCAACTCCAGCTCAATGAAGCCATCGGAGCCAC
CTACGACAATCTGATCAAACTGTCCCTCCGTCATCGACCAGACTTGCTCATCATCGGTGAAATTCGGGATGCGGAAACCG
CTCGAGCAGTCATTCGAGCCAGCCTGACAGGAGCTACCGTTTTCTCAACAGTTCATGCAAGGTCTATTTCGGGTGTCTAT
GCTCGTATGTTGGAATTGGGTGTCGGTCCTGAGGAGTTAAACAATGCCCTTCAAGGTATTGCCTATCAACGTTTAATCGG
GGGAGGAGGTGTGGTAGATTTTGCAAAGGGAAATTACCAAAACCATTCCGCAGACCAGTGGAATGCGCAAATTGATCGGC
TTTTTGCAGCAGGACATATCAGTCTTCGGCAGGCAGAAACAGAAAAAATTACCCTTGGCTCGCCAGCGTAA

Domains

Predicted by InterProScan.

Type II/IV secretion system protein (T2SSE)

(8-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H3MX74

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA Streptococcus gordonii str. Challis substr. CH1

68.387

98.101

0.671
  comGA Streptococcus mutans UA159

67.203

98.418

0.661
  comGA Streptococcus mutans UA140

67.203

98.418

0.661
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

64.63

98.418

0.636
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

64.63

98.418

0.636
  comGA/cglA/cilD Streptococcus pneumoniae D39

64.63

98.418

0.636
  comGA/cglA/cilD Streptococcus pneumoniae R6

64.63

98.418

0.636
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

64.63

98.418

0.636
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

64.516

98.101

0.633
  comGA Lactococcus lactis subsp. cremoris KW2

52.997

100

0.532
  comGA Latilactobacillus sakei subsp. sakei 23K

41.155

87.658

0.361