Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   RSK81_RS12495 Genome accession   NZ_CP135591
Coordinates   2514732..2515496 (-) Length   254 a.a.
NCBI ID   WP_002899424.1    Uniprot ID   A0A0B7GUD9
Organism   Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 2513094..2514445 2514732..2515496 flank 287


Gene organization within MGE regions


Location: 2513094..2515496
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RSK81_RS12480 (RSK81_12480) - 2513094..2514445 (+) 1352 WP_111681466.1 IS3 family transposase -
  RSK81_RS12495 (RSK81_12495) comE 2514732..2515496 (-) 765 WP_002899424.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 254 a.a.        Molecular weight: 29851.13 Da        Isoelectric Point: 8.0162

>NTDB_id=887065 RSK81_RS12495 WP_002899424.1 2514732..2515496(-) (comE) [Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A]
MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY
IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL
KDIFENKGKRVDKA

Nucleotide


Download         Length: 765 bp        

>NTDB_id=887065 RSK81_RS12495 WP_002899424.1 2514732..2515496(-) (comE) [Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A]
ATGAAAGTGTTAGTTTTAGAGGATACCGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT
TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC
TTTATTTTTTGGATATTGACATTAAGGGGGAGGAAACAAAAGGGCTGGAAGTAGCTCAATTTATCCGTCATCATAATCCT
TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT
TATCGATAAAGATATCAACAATGATGCTTTTAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG
AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT
ATCGAAACGACAGGGAGCTCTCATAAACTTCGGATTGTCGGTAAAAATTTTCTTAAGGAGTTTTATGGAACGATAACAGA
TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCACATAAATCTTATCTGGTTAATATTGGCAACATTGTTG
ATTATGACAAGAAAAATCGAGAAATTATTTTTTATGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATTTG
AAAGATATTTTCGAAAATAAAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-244)

Response regulator receiver domain (Response_reg)

(4-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7GUD9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus infantis strain Atu-4

68.4

98.425

0.673
  comE/comE2 Streptococcus gordonii strain NCTC7865

68.4

98.425

0.673
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

68.4

98.425

0.673
  comE Streptococcus mitis NCTC 12261

68

98.425

0.669
  comE Streptococcus mitis SK321

67.2

98.425

0.661
  comE Streptococcus pneumoniae Rx1

66.8

98.425

0.657
  comE Streptococcus pneumoniae D39

66.8

98.425

0.657
  comE Streptococcus pneumoniae R6

66.8

98.425

0.657
  comE Streptococcus pneumoniae TIGR4

66.8

98.425

0.657
  comE/blpR Streptococcus mutans UA159

38.8

98.425

0.382