Detailed information NTG0887065

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: RSK81_RS12495
• Genome accession: NZ_CP135591
• Coordinates: 2514732..2515496 (-)
• Length: 254 a.a.
• NCBI ID: WP_002899424.1
• Uniprot ID: A0A0B7GUD9
• Organism: Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2509732..2520496

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RSK81_RS12475 (RSK81_12475)	-	2510396..2512981 (+)	2586	WP_002927412.1	YfhO family protein	-
RSK81_RS12480 (RSK81_12480)	-	2513094..2514445 (+)	1352	WP_111681466.1	IS3 family transposase	-
RSK81_RS12495 (RSK81_12495)	comE	2514732..2515496 (-)	765	WP_002899424.1	competence system response regulator transcription factor ComE	Regulator
RSK81_RS12500 (RSK81_12500)	comD	2515502..2516836 (-)	1335	WP_002927417.1	competence system sensor histidine kinase ComD	-
RSK81_RS12505 (RSK81_12505)	-	2516864..2516971 (-)	108	WP_002894290.1	hypothetical protein	-
RSK81_RS12515 (RSK81_12515)	rlmH	2517269..2517748 (-)	480	WP_315686997.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
RSK81_RS12520 (RSK81_12520)	htrA	2517952..2519124 (+)	1173	WP_002927420.1	S1C family serine protease	Regulator
RSK81_RS12525 (RSK81_12525)	spo0J	2519188..2519949 (+)	762	WP_315686999.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 254 a.a.
• Molecular weight: 29851.13 Da
• Isoelectric Point: 8.0162

>NTDB_id=887065 RSK81_RS12495 WP_002899424.1 2514732..2515496(-) (comE) [Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A]
MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY
IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL
KDIFENKGKRVDKA

Nucleotide

• Length: 765 bp

>NTDB_id=887065 RSK81_RS12495 WP_002899424.1 2514732..2515496(-) (comE) [Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A]
ATGAAAGTGTTAGTTTTAGAGGATACCGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT
TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC
TTTATTTTTTGGATATTGACATTAAGGGGGAGGAAACAAAAGGGCTGGAAGTAGCTCAATTTATCCGTCATCATAATCCT
TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT
TATCGATAAAGATATCAACAATGATGCTTTTAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG
AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT
ATCGAAACGACAGGGAGCTCTCATAAACTTCGGATTGTCGGTAAAAATTTTCTTAAGGAGTTTTATGGAACGATAACAGA
TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCACATAAATCTTATCTGGTTAATATTGGCAACATTGTTG
ATTATGACAAGAAAAATCGAGAAATTATTTTTTATGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATTTG
AAAGATATTTTCGAAAATAAAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (4-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus infantis strain Atu-4	68.4	98.425	0.673
comE/comE2	Streptococcus gordonii strain NCTC7865	68.4	98.425	0.673
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	68.4	98.425	0.673
comE	Streptococcus mitis NCTC 12261	68	98.425	0.669
comE	Streptococcus mitis SK321	67.2	98.425	0.661
comE	Streptococcus pneumoniae Rx1	66.8	98.425	0.657
comE	Streptococcus pneumoniae D39	66.8	98.425	0.657
comE	Streptococcus pneumoniae R6	66.8	98.425	0.657
comE	Streptococcus pneumoniae TIGR4	66.8	98.425	0.657
comE/blpR	Streptococcus mutans UA159	38.8	98.425	0.382