Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   RRU92_RS02110 Genome accession   NZ_CP135436
Coordinates   420504..421688 (+) Length   394 a.a.
NCBI ID   WP_315640222.1    Uniprot ID   A0AA96MR86
Organism   Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 415504..426688
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RRU92_RS02075 (RRU92_02075) - 416362..416904 (+) 543 WP_061863863.1 TetR/AcrR family transcriptional regulator -
  RRU92_RS02085 (RRU92_02085) comE 417333..418085 (-) 753 WP_049530388.1 competence system response regulator transcription factor ComE Regulator
  RRU92_RS02090 (RRU92_02090) comD 418082..419401 (-) 1320 WP_315640220.1 competence system sensor histidine kinase ComD Regulator
  RRU92_RS02095 (RRU92_02095) - 419424..419558 (-) 135 WP_315640221.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  RRU92_RS02105 (RRU92_02105) rlmH 419841..420320 (-) 480 WP_153224633.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  RRU92_RS02110 (RRU92_02110) htrA 420504..421688 (+) 1185 WP_315640222.1 S1C family serine protease Regulator
  RRU92_RS02115 (RRU92_02115) spo0J 421745..422503 (+) 759 WP_153224631.1 ParB/RepB/Spo0J family partition protein Regulator
  RRU92_RS02120 (RRU92_02120) dnaA 422725..424080 (+) 1356 WP_153224630.1 chromosomal replication initiator protein DnaA -
  RRU92_RS02125 (RRU92_02125) dnaN 424238..425374 (+) 1137 WP_248035104.1 DNA polymerase III subunit beta -
  RRU92_RS02130 (RRU92_02130) - 425441..425635 (+) 195 WP_000285188.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 394 a.a.        Molecular weight: 41527.41 Da        Isoelectric Point: 5.2110

>NTDB_id=886512 RRU92_RS02110 WP_315640222.1 420504..421688(+) (htrA) [Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006]
MKNLKTSSKKWGQLLVVILISFFSGVLGTFTTLQLSQKQNTNPTNTTTVSKTAVKNENSTTQAVDKVKDAVVSVITYSAN
SQNSLFGSTETDTDTNTEQVSSEGSGVIYKKEGNFAYLVTNTHVINGAKKVDIRLADGTKVPGEIVGSDTYSDIAVVKIA
ADKVTTVAEFGDSDQLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLI
NIQGQVIGITSSKIATNGGTSVEGLGFAIPSNDAINIINQLEKNGKVTRPALGIQMVNLSNLSSTDLQRLNVPSSVTAGV
VVRSVITSMPANGHLQQYDVITKVDDKAISSTTELQSALYSHSIGDSMTITYYRNGKEETTTIKLDKSTSDLEQ

Nucleotide


Download         Length: 1185 bp        

>NTDB_id=886512 RRU92_RS02110 WP_315640222.1 420504..421688(+) (htrA) [Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006]
ATGAAAAACTTAAAAACTAGTTCCAAAAAATGGGGACAACTTTTAGTAGTCATTCTCATTAGCTTTTTTAGTGGTGTTTT
AGGTACTTTTACGACATTGCAGCTAAGTCAAAAACAAAACACTAATCCAACAAATACCACCACTGTCAGCAAAACAGCTG
TAAAAAATGAAAACTCAACCACACAGGCAGTCGATAAAGTTAAAGATGCTGTAGTATCTGTCATTACTTACTCCGCAAAC
TCCCAAAATAGTTTATTTGGATCTACAGAGACTGATACAGATACAAATACTGAGCAAGTATCTAGTGAAGGTTCTGGAGT
TATTTATAAAAAAGAAGGTAACTTTGCTTACCTCGTAACCAATACTCACGTTATTAATGGCGCTAAAAAAGTTGATATTC
GTTTAGCAGATGGGACTAAAGTTCCAGGTGAAATTGTTGGTTCTGATACTTATTCTGACATTGCAGTTGTAAAAATTGCT
GCAGATAAGGTGACTACAGTAGCCGAATTTGGAGATTCTGATCAACTAACAGTTGGAGAAACAGCTATTGCAATCGGAAG
CCCTCTAGGTTCTGAATATGCCAATACCGTGACACAAGGCATCGTGTCAAGTTTGAATAGAAATGTTTCTTTAAAATCTG
AAGATGGACAAGCTATCTCTACAAAGGCTATCCAAACAGATACAGCCATCAACCCTGGAAACTCTGGCGGTCCCTTAATC
AATATTCAGGGACAAGTAATCGGAATTACATCTAGTAAAATCGCCACAAACGGTGGAACGTCTGTGGAAGGACTTGGTTT
TGCCATTCCTTCAAACGATGCCATCAATATTATCAATCAATTGGAAAAGAATGGAAAAGTCACTCGACCAGCCTTGGGCA
TTCAAATGGTCAACCTTTCAAATCTTAGTAGCACTGATTTACAAAGATTGAATGTACCATCAAGTGTCACTGCAGGAGTA
GTTGTTCGTTCTGTTATAACTAGTATGCCTGCCAATGGACATCTACAACAATATGACGTCATTACAAAAGTGGATGATAA
AGCTATTTCTTCAACTACTGAATTACAAAGTGCTCTATATAGCCATTCTATCGGAGATAGCATGACCATTACATACTACC
GTAATGGCAAGGAAGAAACAACTACCATTAAATTAGATAAGAGTACTAGTGATTTGGAACAATAG

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(290-385)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

80.203

100

0.802
  htrA Streptococcus pneumoniae Rx1

80.203

100

0.802
  htrA Streptococcus pneumoniae D39

80.203

100

0.802
  htrA Streptococcus pneumoniae R6

80.203

100

0.802
  htrA Streptococcus pneumoniae TIGR4

80.203

100

0.802
  htrA Streptococcus gordonii str. Challis substr. CH1

67.677

100

0.68
  htrA Streptococcus mutans UA159

53.435

99.746

0.533